Citocalasinas produzidas por Xylaria sp., um fungo endofítico de Piper aduncum (piperaceae) Cytochalasins produced by Xylaria sp., an endophytic fungus from Piper aduncum
- Geraldo H. Silva
- Camila M. de Oliveira
- Helder L. Teles
- Vanderlan da S. Bolzani
- Angela R. Araujo
- Ludwig H. Pfenning
- Maria Claudia M. Young
- Claudio M. Costa-Neto
- Renato Haddad
- Marcos N. Eberlin
Publication date
January 2010
DOI Publisher
FapUNIFESP (SciELO) ISSN
0100-4042 Journal
Química Nova Citation count (estimate)
9Abstract
A chemical study on the EtOAc extract produced by Xylaria sp., an endophytic fungus from Piper aduncum, resulted in the isolation of a new cytochalasin 1, along with five known 19,20-epoxycytochalasin D (2), C (3), N (4), Q (5), and R (6). The 1-6 were evaluated against the fungi C. cladosporioides and C. sphaerospermum and only 5 showed weak activity. The cytotoxicity in vitro against HeLA and CHO cells lines were investigated and the cytochalasins 2-4, and 6 showed a strong activity against HeLA. The DNAdamaging activity of 1-6 were also investigated against mutant strains of S. cerevisiae
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