Issues with data transformation in genome-wide association studies for phenotypic variability [v1; ref status: indexed, http://f1000r.es/1xl]

The purpose of this correspondence is to discuss and clarify a few points about data transformation used in genome-wide association studies, especially for phenotypic variability. By commenting on the recent publication by Sun et al. in the American Journal of Human Genetics, we emphasize the importance of statistical power in detecting functional loci and the real meaning of the scale of the phenotype in practice