We investigate supersymmetric SU(5) grand-unified theories (GUTs) realized in 5 space-time dimensions and broken down to the MSSM by SU(5)-violating boundary conditions on a S^1/(Z_2 x Z_2') orbifold with two 3-branes. The doublet-triplet splitting problem is entirely avoided by locating the MSSM Higgs doublets on the brane on which SU(5) is not a good symmetry. An extremely simple model is then described in which the MSSM matter is also located on this SU(5)-violating brane. Although this model does not unify the MSSM matter within SU(5) multiplets, it explains gauge coupling unification. A second model with MSSM matter in the SU(5)-symmetric bulk preserves both the SU(5) explanation of fermion quantum numbers as well as gauge-coupling uni...