Engineered MOFs and Enzymes for the Synthesis of Active Pharmaceutical Ingredients

© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim The latest strategies in the design and synthesis of metal-organic frameworks as heterogeneous catalysts in organic synthesis are compared with biocatalyzed transformations, as a step forward to a more convenient industrial production of pharmaceuticals. Relevant C−C and C−N bond forming reactions that are both chemo- and bio- catalyzed by synthetic MOFs and in vitro evolved and/or promiscuous enzymes with the aim of obtaining key bioactive scaffolds in a sustainable, competitive and cost-efficient manner, are thoroughly discussed in this mini review.status: publishe