BACKGROUND: Targeted delivery of the angiogenic factor, VEGF, to motor neurons prolongs survival in rodent models of ALS, while mice expressing reduced VEGF levels develop motor neuron degeneration reminiscent of ALS, raising the question whether VEGF contributes to the pathogenesis of ALS. An initial association study reported that VEGF haplotypes conferred an increased susceptibility to ALS in humans, but later studies challenged this initial finding. Methods and Findings: A meta-analysis was undertaken to critically reappraise whether any of the three common VEGF gene variations (-2578C/A, -1154G/A and -634G/C) increase the risk of ALS. Over 7,000 individuals from 8 European and 3 American populations were included in the analysis. Poole...
Amyotrophic lateral sclerosis (ALS) is a progressive, neurodegenerative disease characterized by los...
Objective: To determine whether 5 single nucleotide polymorphisms (SNPs) associate with ALS in 3 dif...
Item does not contain fulltextBACKGROUND: ALS is believed to be multifactorial in origin with modify...
Background: Targeted delivery of the angiogenic factor, vascular endothelial growth factor (VEGF), t...
Background: Targeted delivery of the angiogenic factor, vascular endothelial growth factor (VEGF), t...
Amyotrophic lateral sclerosis (ALS) is an incurable degenerative disorder of motoneurons. We recentl...
Lambrechts et al. reported in 2003 that homozygotes with specific haplotypes (AAG; AGG) of VEGF incr...
A linkage and association of the VEGF (vascular endothelial growth factor) C2578A polymorphism and a...
Background: The use of lipid-lowering drugs is still highly controversial in patients with amyotroph...
To investigate the role of vascular endothelial growth factor (VEGF) and angiogenin (ANG) as genetic...
Contains fulltext : 80041.pdf (publisher's version ) (Closed access)A genome-wide ...
ABSTRACT: BACKGROUND: Vascular endothelial growth factor (VEGF) is an endothelial cell mitogen that ...
To investigate the role of vascular endothelial growth factor (VEGF) and angiogenin (ANG) as genetic...
The cause of sporadic ALS is largely unknown, but genetic factors are thought to play a significant ...
Background: Mutations in HFE, a gene defect that can disrupt iron metabolism, have been implicated i...
Amyotrophic lateral sclerosis (ALS) is a progressive, neurodegenerative disease characterized by los...
Objective: To determine whether 5 single nucleotide polymorphisms (SNPs) associate with ALS in 3 dif...
Item does not contain fulltextBACKGROUND: ALS is believed to be multifactorial in origin with modify...
Background: Targeted delivery of the angiogenic factor, vascular endothelial growth factor (VEGF), t...
Background: Targeted delivery of the angiogenic factor, vascular endothelial growth factor (VEGF), t...
Amyotrophic lateral sclerosis (ALS) is an incurable degenerative disorder of motoneurons. We recentl...
Lambrechts et al. reported in 2003 that homozygotes with specific haplotypes (AAG; AGG) of VEGF incr...
A linkage and association of the VEGF (vascular endothelial growth factor) C2578A polymorphism and a...
Background: The use of lipid-lowering drugs is still highly controversial in patients with amyotroph...
To investigate the role of vascular endothelial growth factor (VEGF) and angiogenin (ANG) as genetic...
Contains fulltext : 80041.pdf (publisher's version ) (Closed access)A genome-wide ...
ABSTRACT: BACKGROUND: Vascular endothelial growth factor (VEGF) is an endothelial cell mitogen that ...
To investigate the role of vascular endothelial growth factor (VEGF) and angiogenin (ANG) as genetic...
The cause of sporadic ALS is largely unknown, but genetic factors are thought to play a significant ...
Background: Mutations in HFE, a gene defect that can disrupt iron metabolism, have been implicated i...
Amyotrophic lateral sclerosis (ALS) is a progressive, neurodegenerative disease characterized by los...
Objective: To determine whether 5 single nucleotide polymorphisms (SNPs) associate with ALS in 3 dif...
Item does not contain fulltextBACKGROUND: ALS is believed to be multifactorial in origin with modify...