Metabolic alterations are a hallmark of cancer. While determining metabolic changes in vitro has delivered valuable insight into the metabolism of cancer cells, it emerges that determining the in vivo metabolism adds an additional layer of information. Here, we therefore describe how to measure the in vivo metabolism of cancer tissue using 13C glucose infusions in mice.status: publishe
Background: There is growing interest in the analysis of tumor metabolism to identify cancer-specifi...
In vivo studies of hepatic carbohydrate metabolism in (genetically modified) conscious mice are hamp...
Metabolic differences among and within tumors can be an important determinant in cancer treatment ou...
Metastasis formation is the leading cause of death in cancer patients. It has recently emerged that ...
Cancer metabolism is wired to sustain uncontrollable cell proliferation and ensure cell survival. Gi...
Abstract Background There is growing interest in the analysis of tumor metabolism to identify canc...
Tracer-based metabolomics is a special form of targeted metabolomics in which the isotopomer distrib...
The metabolic engineer's toolbox, comprising stable isotope tracers, flux estimation and analysis, p...
Metabolic reprogramming is a key step in oncogenic transformation including the activation of energy...
ABSTRACT: It is well established that most cancer cells take up an increased amount of glucose relat...
iii Metabolism is a complex process that transforms nutrients into energy, reducing power, and biosy...
Measurements of hyperpolarized 13C label exchange between injected [1-13C]pyruvate and the endogenou...
Mapping enzymatic activity in space and time is critical for understanding the molecular basis of ce...
Introduction: Breast cancer is prevalent health issue in women. Currently PET scanning is used as a ...
Tumor cells can adopt alternative metabolic pathways during oncogenesis. This is an event characteri...
Background: There is growing interest in the analysis of tumor metabolism to identify cancer-specifi...
In vivo studies of hepatic carbohydrate metabolism in (genetically modified) conscious mice are hamp...
Metabolic differences among and within tumors can be an important determinant in cancer treatment ou...
Metastasis formation is the leading cause of death in cancer patients. It has recently emerged that ...
Cancer metabolism is wired to sustain uncontrollable cell proliferation and ensure cell survival. Gi...
Abstract Background There is growing interest in the analysis of tumor metabolism to identify canc...
Tracer-based metabolomics is a special form of targeted metabolomics in which the isotopomer distrib...
The metabolic engineer's toolbox, comprising stable isotope tracers, flux estimation and analysis, p...
Metabolic reprogramming is a key step in oncogenic transformation including the activation of energy...
ABSTRACT: It is well established that most cancer cells take up an increased amount of glucose relat...
iii Metabolism is a complex process that transforms nutrients into energy, reducing power, and biosy...
Measurements of hyperpolarized 13C label exchange between injected [1-13C]pyruvate and the endogenou...
Mapping enzymatic activity in space and time is critical for understanding the molecular basis of ce...
Introduction: Breast cancer is prevalent health issue in women. Currently PET scanning is used as a ...
Tumor cells can adopt alternative metabolic pathways during oncogenesis. This is an event characteri...
Background: There is growing interest in the analysis of tumor metabolism to identify cancer-specifi...
In vivo studies of hepatic carbohydrate metabolism in (genetically modified) conscious mice are hamp...
Metabolic differences among and within tumors can be an important determinant in cancer treatment ou...