An amino acid motif in HLA-DRβ1 distinguishes patients with uveitis in juvenile idiopathic arthritis
- Haasnoot, Anne-Mieke JW
- Schilham, Marco W
- Kamphuis, Sylvia
- Hissink Muller, Petra CE
- Heiligenhaus, Arnd
- Foell, Dirk
- Minden, Kirsten
- Ophoff, Roel A
- Radstake, Timothy RDJ
- Den Hollander, Anneke I
- Reinards, Tjitske HCM
- Hiddingh, Sanne
- Schalij-Delfos, Nicoline E
- Hoppenreijs, Esther PAH
- van Rossum, Marion AJ
- Wouters, Carine
- Saurenmann, Rotraud K
- van den Berg, J Merlijn
- Wulffraat, Nico M
- Ten Cate, Rebecca
- de Boer, Joke H
- Pulit, Sara L
- Kuiper, Jonas JW
DOIAbstract
Uveitis is a visually-debilitating disorder that affects up to 30% of children with the most common forms of juvenile idiopathic arthritis (JIA). The disease mechanisms predisposing only a subgroup of children to uveitis are unknown. To identify genetic susceptibility loci for uveitis in JIA, we conducted a genome-wide association study totalling 522 JIA cases.status: accepte
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