Human hepatocellular carcinomas (HCCs) expressing the biliary/hepatic progenitor cell marker keratin 19 (K19) have been linked with a poor prognosis and exhibit an increase in platelet-derived growth factor receptor α (PDGFRα) and laminin beta 1 (LAMB1) expression. PDGFRα has been reported to induce de novo synthesis of LAMB1 protein in a Sjogren syndrome antigen B (La/SSB)-dependent manner in a murine metastasis model. However, the role of this cascade in human HCC remains unclear. This study focused on the functional role of the PDGFRα-La/SSB-LAMB1 pathway and its molecular link to K19 expression in human HCC. In surgical HCC specimens from a cohort of 136 patients, PDGFRα expression correlated with K19 expression, microvascular invasion ...
BACKGROUND Cholangiocarcinomas (CCAs) are highly desmoplastic neoplasms with a tumour microenvironme...
Chronic liver injury leads to fibrosis, cirrhosis, and loss of liver function. Liver cirrhosis is th...
Abstract Background Platelet-derived growth factor receptor α (PDGFRα) expression is increased in ac...
Hepatocellular carcinoma (HCC) is amongst the top common cancers and the third cause of cancer relat...
Hepatocellular cancer (HCC) is a disease of poor prog-nosis. Identifying novel molecular aberrations...
The expression of the hepatic progenitor cell marker keratin 19 (K19) in canine hepatocellular carci...
OBJECTIVE: Keratin (K)19, a biliary/hepatic progenitor cell (HPC) marker, is expressed in a subset o...
BACKGROUND AND AIMS: Platelet-derived growth factor receptor alpha (PDGFRα) is suggested as a prog...
BACKGROUND /Aims. In cholangiocarcinoma, early metastatic spread via lymphatic vessels often preclu...
Cholangiocarcinoma (CCA) is characterized by an abundant stromal reaction. Cancer-associated fibrobl...
Hepatocellular carcinoma (HCC) is one of the most prevalent cancer types in the Western world and in...
Aberrant platelet-derived growth factor receptor-α (PDGFRα) signaling is evident in a subset of hepa...
Introduction: Hepatocellular carcinoma (HCC) typically develops in cirrhotic livers, with increased ...
Thesis (Ph.D.)--University of Washington, 2014Platelet derived growth factor receptor alpha (PDGFRα)...
Keratin (KRT) 19 is a poor prognostic marker for hepatocellular carcinoma (HCC); however, regulatory...
BACKGROUND Cholangiocarcinomas (CCAs) are highly desmoplastic neoplasms with a tumour microenvironme...
Chronic liver injury leads to fibrosis, cirrhosis, and loss of liver function. Liver cirrhosis is th...
Abstract Background Platelet-derived growth factor receptor α (PDGFRα) expression is increased in ac...
Hepatocellular carcinoma (HCC) is amongst the top common cancers and the third cause of cancer relat...
Hepatocellular cancer (HCC) is a disease of poor prog-nosis. Identifying novel molecular aberrations...
The expression of the hepatic progenitor cell marker keratin 19 (K19) in canine hepatocellular carci...
OBJECTIVE: Keratin (K)19, a biliary/hepatic progenitor cell (HPC) marker, is expressed in a subset o...
BACKGROUND AND AIMS: Platelet-derived growth factor receptor alpha (PDGFRα) is suggested as a prog...
BACKGROUND /Aims. In cholangiocarcinoma, early metastatic spread via lymphatic vessels often preclu...
Cholangiocarcinoma (CCA) is characterized by an abundant stromal reaction. Cancer-associated fibrobl...
Hepatocellular carcinoma (HCC) is one of the most prevalent cancer types in the Western world and in...
Aberrant platelet-derived growth factor receptor-α (PDGFRα) signaling is evident in a subset of hepa...
Introduction: Hepatocellular carcinoma (HCC) typically develops in cirrhotic livers, with increased ...
Thesis (Ph.D.)--University of Washington, 2014Platelet derived growth factor receptor alpha (PDGFRα)...
Keratin (KRT) 19 is a poor prognostic marker for hepatocellular carcinoma (HCC); however, regulatory...
BACKGROUND Cholangiocarcinomas (CCAs) are highly desmoplastic neoplasms with a tumour microenvironme...
Chronic liver injury leads to fibrosis, cirrhosis, and loss of liver function. Liver cirrhosis is th...
Abstract Background Platelet-derived growth factor receptor α (PDGFRα) expression is increased in ac...