Extracellular matrix metalloproteinase inducer (EMMPRIN) is a potential biomarker of angiogenesis in proliferative diabetic retinopathy
- Abu El-Asrar, Ahmed M
- Ahmad, Ajmal
- Alam, Kaiser
- Siddiquei, Mohammad Mairaj
- Mohammad, Ghulam
- De Hertogh, Gert
- Mousa, Ahmed
- Opdenakker, Ghislain
DOIAbstract
Extracellular matrix metalloproteinase inducer (EMMPRIN) promotes angiogenesis through matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF) production. We investigated the expression levels of EMMPRIN and correlated these levels with VEGF, MMP-1 and MMP-9 in proliferative diabetic retinopathy (PDR). In addition, we examined the expression of EMMPRIN in the retinas of diabetic rats and the effect of EMMPRIN on the induction of angiogenesis regulatory factors in human retinal microvascular endothelial cells (HRMECs).status: publishe
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