Genetic risk score Mendelian randomization shows that obesity measured as body mass index, but not waist:hip ratio, is causal for endometrial cancer
- Painter, Jodie N
- O'Mara, Tracy A
- Marquart, Louise
- Webb, Penelope M
- Attia, John
- Medland, Sarah E
- Cheng, Timothy
- Dennis, Joe
- Holliday, Elizabeth G
- McEvoy, Mark
- Scott, Rodney J
- Ahmed, Shahana
- Healey, Catherine S
- Shah, Mitul
- Gorman, Maggie
- Martin, Lynn
- Hodgson, Shirley V
- Beckmann, Matthias W
- Ekici, Arif B
- Fasching, Peter A
- Hein, Alexander
- Rübner, Matthias
- Czene, Kamila
- Darabi, Hatef
- Hall, Per
- Li, Jingmei
- Dork, Thilo
- Durst, Matthias
- Hillemanns, Peter
- Runnebaum, Ingo B
- Amant, Frédéric
- Annibali, Daniela
- Depreeuw, Jeroen
- Lambrechts, Diether
- Neven, Patrick
- Cunningham, Julie M
- Dowdy, Sean C
- Goode, Ellen L
- Fridley, Brooke L
- Winham, Stacey J
- Njolstad, Tormund S
- Salvesen, Helga B
- Trovik, Jone
- Werner, Henrica Mj
- Ashton, Katie A
- Otton, Geoffrey
- Proietto, Anthony
- Mints, Miriam
- Tham, Emma
- Bolla, Manjeet K
- Michailidou, Kyriaki
- Wang, Qin
- Tyrer, Jonathan P
- Hopper, John L
- Peto, Julian
- Swerdlow, Anthony J
- Burwinkel, Barbara
- Brenner, Hermann
- Meindl, Alfons
- Brauch, Hiltrud
- Lindblom, Annika
- Chang-Claude, Jenny
- Couch, Fergus J
- Giles, Graham G
- Kristensen, Vessela N
- Cox, Angela
- Pharoah, Paul DP
- Tomlinson, Ian
- Dunning, Alison M
- Easton, Douglas F
- Thompson, Deborah J
- Spurdle, Amanda B
Publication date
November 2016
DOI Publisher
American Association for Cancer Research (AACR) Journal
Cancer Epidemiology Biomarkers & PreventionAbstract
The strongest known risk factor for endometrial cancer (EC) is obesity. To determine whether single nucleotide polymorphisms (SNPs) associated with increased body mass index (BMI) or waist-hip ratio (WHR) are associated with EC risk, independent of measured BMI, we investigated relationships between 77 BMI and 47 WHR SNPs and EC in 6,609 cases and 37,926 country-matched controls.status: publishe
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