A classical conditioning framework is often used for clinical reasoning about pain that persists after tissue healing. However, experimental studies demonstrating classically conditioned pain in humans are lacking. The current study tested whether non-nociceptive somatosensory stimuli can come to modulate pain threshold after being paired with painful nociceptive stimuli in healthy humans. We used a differential simultaneous conditioning paradigm in which one non-painful vibrotactile conditioned stimulus (CS+) was simultaneously paired with an unconditioned painful laser stimulus (US), while another vibrotactile stimulus (CS-) was paired with a non-painful laser stimulus. After acquisition, at-pain-threshold laser stimuli were delivered sim...
Conditioned pain modulation (CPM) and temporal summation of pain (TSP) are 2 experimental paradigms ...
Innocuous cues that become associated with pain can enhance pain. This is termed classically conditi...
There is an ongoing debate about whether pain can be classically conditioned, but surprisingly, evid...
A classical conditioning framework is often used for clinical reasoning about pain that persists aft...
A classical conditioning framework is often used for clinical reasoning about pain that persists aft...
Background: Classical conditioning has frequently been shown to be capable of evoking fear of pain a...
OBJECTIVE : Associative learning has been proposed as a mechanism behind the persistence of pain aft...
OBJECTIVE : Associative learning has been proposed as a mechanism behind the persistence of pain aft...
Purpose of ReviewIt has been known for decades that classical conditioning influences pain perceptio...
BACKGROUND: Clinical scenarios of repeated pain usually involve both nociceptive and non-nociceptive...
BACKGROUND: . Clinical scenarios of repeated pain usually involve both nociceptive and non-nocicepti...
Reduced pain perception during painful stimulation to another body region (ie, conditioned pain modu...
AIMS: Non-nociceptive somatosensory input, such as tactile or proprioceptive information, always pre...
This study investigated the relationship between pain sensitivity, adaptability, and potency of endo...
Background Picturing the complexity of pain in human experimental settings has increased the predict...
Conditioned pain modulation (CPM) and temporal summation of pain (TSP) are 2 experimental paradigms ...
Innocuous cues that become associated with pain can enhance pain. This is termed classically conditi...
There is an ongoing debate about whether pain can be classically conditioned, but surprisingly, evid...
A classical conditioning framework is often used for clinical reasoning about pain that persists aft...
A classical conditioning framework is often used for clinical reasoning about pain that persists aft...
Background: Classical conditioning has frequently been shown to be capable of evoking fear of pain a...
OBJECTIVE : Associative learning has been proposed as a mechanism behind the persistence of pain aft...
OBJECTIVE : Associative learning has been proposed as a mechanism behind the persistence of pain aft...
Purpose of ReviewIt has been known for decades that classical conditioning influences pain perceptio...
BACKGROUND: Clinical scenarios of repeated pain usually involve both nociceptive and non-nociceptive...
BACKGROUND: . Clinical scenarios of repeated pain usually involve both nociceptive and non-nocicepti...
Reduced pain perception during painful stimulation to another body region (ie, conditioned pain modu...
AIMS: Non-nociceptive somatosensory input, such as tactile or proprioceptive information, always pre...
This study investigated the relationship between pain sensitivity, adaptability, and potency of endo...
Background Picturing the complexity of pain in human experimental settings has increased the predict...
Conditioned pain modulation (CPM) and temporal summation of pain (TSP) are 2 experimental paradigms ...
Innocuous cues that become associated with pain can enhance pain. This is termed classically conditi...
There is an ongoing debate about whether pain can be classically conditioned, but surprisingly, evid...