PROCLAIM: Randomized Phase III Trial of Pemetrexed-Cisplatin or Etoposide-Cisplatin Plus Thoracic Radiation Therapy Followed by Consolidation Chemotherapy in Locally Advanced Nonsquamous Non-Small-Cell Lung Cancer

Final results from a Phase II study of pemetrexed and cisplatin with concurrent thoracic radiation after Pem-Cis induction in patients with unresectable locally advanced non-squamous non-small cell lung cancer (NSCLC)

Garrido, Pilar
Engel-Riedel, Walburga
Serke, Monika
Giraud, Philippe
Ricardi, Umberto
Vallejo, Carmen
Visseren-Grul, Carla
Ameryckx, Sophie
Soldatenkova, Victoria
Chouaki, Nadia
Novello, Silvia

May 2015

AbstractObjectivesThis single-arm multicenter Phase II study investigated the efficacy and safety of...

Original Article A Phase II Study of Cisplatin and Irinotecan As Induction Chemotherapy Followed by Concomitant Thoracic Radiotherapy with Weekly Low-dose Irinotecan in Unresectable, Stage III,

Non-small Cell
Lung Cancer Jcog
Koji Takeda
Shunichi Negoro
Masahiro Tanaka
Haruhiko Fukuda
Kazuhiko Nakagawa
Masaaki Kawahara
Hiroshi Semba
Shinzoh Kudoh
Toshiyuki Sawa
Nagahiro Saijo

January 2010

Objective: It is important to identify optimal regimens of cisplatin-based, third-generation che-mot...

Phase 2 Study of Pemetrexed Plus Carboplatin, or Pemetrexed Plus Cisplatin with Concurrent Radiation Therapy Followed by Pemetrexed Consolidation in Patients with Favorable-Prognosis Inoperable Stage IIIA/B Non–Small-Cell Lung Cancer

Choy, Hak
Schwartzberg, Lee S.
Dakhil, Shaker R.
Garon, Edward B.
Gerber, David E.
Choksi, Janak K.
Govindan, Ramaswamy
Peng, Guangbin
Koustenis, Andrew
Treat, Joseph
Obasaju, Coleman

October 2013

IntroductionThere is no consensus chemotherapy regimen with concurrent radiotherapy (RT) for inopera...

PROCLAIM: Randomized Phase III Trial of Pemetrexed-Cisplatin or Etoposide-Cisplatin Plus Thoracic Radiation Therapy Followed by Consolidation Chemotherapy in Locally Advanced Nonsquamous Non-Small-Cell Lung Cancer

Senan, Suresh
Brade, Anthony
Wang, Lu-Hua
Vansteenkiste, Johan
Dakhil, Shaker
Biesma, Bonne
Martinez Aguillo, Maite
Aerts, Joachim
Govindan, Ramaswamy
Rubio-Viqueira, Belén
Lewanski, Conrad
Gandara, David
Choy, Hak
Mok, Tony
Hossain, Anwar
Iscoe, Neill
Treat, Joseph
Koustenis, Andrew
San Antonio, Bélen
Chouaki, Nadia
Vokes, Everett

March 2016

The phase III PROCLAIM study evaluated overall survival (OS) of concurrent pemetrexed-cisplatin and ...

Chemotherapy in non-small cell lung cancer: opportunities for advancement

Mani Akhtari
Eric H. Bernicker
Bin S. Teh

June 2016

Abstract Locally advanced non-small cell lung cancer (NSCLC) continues to be a challenging disease t...

Three-Year Follow-Up of a Randomized Phase II Trial on Refinement of Early-Stage NSCLC Adjuvant Chemotherapy with Cisplatin and Pemetrexed versus Cisplatin and Vinorelbine (the TREAT Study)

Kreuter, Michael
Vansteenkiste, Johan
Fischer, Jürgen R
Eberhardt, Wilfried E
Zabeck, Heike
Kollmeier, Jens
Serke, Monika
Frickhofen, Norbert
Reck, Martin
Engel-Riedel, Walburga
Neumann, Silke
Thomeer, Michiel
Schumann, Christian
De Leyn, Paul
Graeter, Thomas
Stamatis, Georgios
Griesinger, Frank

January 2016

Adjuvant chemotherapy in non-small cell lung cancer (NSCLC) improves survival but is associated with...

Treatment rationale and study design for a phase III, double-blind, placebo-controlled study of maintenance pemetrexed plus best supportive care versus best supportive care immediately following induction treatment with pemetrexed plus cisplatin for advanced nonsquamous non-small cell lung cancer.

Paz-Ares, Luis G.
Altug, Sedat.
Vaury, Alexandra T.
Jaime, Jesús C.
Russo, Francesca.
Visseren-Grul, Carla.

March 2010

TRIAL REGISTRATION: Trial Registry: Clinicaltrials.gov REGISTRATION NUMBER: NCT00789373 TRIAL ABBREV...

Treatment rationale and study design for a phase III, double-blind, placebo-controlled study of maintenance pemetrexed plus best supportive care versus best supportive care immediately following induction treatment with pemetrexed plus cisplatin for advanced nonsquamous non-small cell lung cancer.

Paz-Ares, Luis G.
Altug, Sedat.
Vaury, Alexandra T.
Jaime, Jesús C.
Russo, Francesca.
Visseren-Grul, Carla.

March 2010

TRIAL REGISTRATION: Trial Registry: Clinicaltrials.gov REGISTRATION NUMBER: NCT00789373 TRIAL ABBREV...

Treatment rationale and study design for a phase III, double-blind, placebo-controlled study of maintenance pemetrexed plus best supportive care versus best supportive care immediately following induction treatment with pemetrexed plus cisplatin for advanced nonsquamous non-small cell lung cancer.

Paz-Ares, Luis G.
Altug, Sedat.
Vaury, Alexandra T.
Jaime, Jesús C.
Russo, Francesca.
Visseren-Grul, Carla.

March 2010

TRIAL REGISTRATION: Trial Registry: Clinicaltrials.gov REGISTRATION NUMBER: NCT00789373 TRIAL ABBREV...

Phase III Study of Surgery Versus Definitive Concurrent Chemoradiotherapy Boost in Patients With Resectable Stage IIIA(N2) and Selected IIIB Non-Small-Cell Lung Cancer After Induction Chemotherapy and Concurrent Chemoradiotherapy (ESPATUE)

Eberhardt, Wilfried Ernst Erich
Pöttgen, Christoph
Gauler, Thomas Christoph
Friedel, Godehard
Veit, Stefanie
Heinrich, Vanessa
Welter, Stefan
Budach, Wilfried
Spengler, Werner
Kimmich, Martin
Fischer, Berthold
Schmidberger, Heinz
De Ruysscher, Dirk
Belka, Claus
Cordes, Sebastian
Hepp, Rodrigo
Lütke-Brintrup, Diana
Lehmann, Nils
Schuler, Martin
Jöckel, Karl-Heinz
Stamatis, Georgios
Stuschke, Martin

December 2015

Concurrent chemoradiotherapy with or without surgery are options for stage IIIA(N2) non-small-cell l...

A phase III randomised study comparing concomitant radiochemotherapy with cisplatin and docetaxel as induction versus consolidation treatment in patients with locally advanced unresectable non-small cell lung cancer

Sculier, Jean-Paul
Giner, Vicente
Paesmans, Marianne
Leclercq, Nathalie
Van Houtte, Paul
Lafitte, Jean-Jacques
Berghmans, Thierry
Meert, Anne-Pascale
Scherpereel, Arnaud
Roelandts, Martine
Van Cutsem, O
Colinet, Benoît
Bonduelle, Y.

March 2018

Objectives: To assess if induction radiochemotherapy followed by consolidation chemotherapy (arm A) ...

Phase II Study of Pemetrexed and Cisplatin, with Chest Radiotherapy Followed by Docetaxel in Patients with Stage III Non-small Cell Lung Cancer

Gadgeel, Shirish M.
Ruckdeschel, John C.
Patel, Bhaumik B.
Wozniak, Antoinette
Konski, Andre
Valdivieso, Manuel
Hackstock, Deborah
Chen, Wei
Belzer, Kimberly
Burger, Angelika M.
Marquette, Lauren
Turrisi, Andrew

May 2011

BackgroundPemetrexed has emerged as one of the most active agents for the treatment of patients with...

PARAMOUNT: Final Overall Survival Results of the Phase III Study of Maintenance Pemetrexed Versus Placebo Immediately After Induction Treatment With Pemetrexed Plus Cisplatin for Advanced Nonsquamous Non–Small-Cell Lung

Luis G. Paz-ares
Mircea Dediu
Michael Thomas
Jean-louis Pujol
Paolo Bidoli
Olivier Molinier
Tarini Prasad Sahoo
Eckart Laack
Martin Reck
Symantha Melemed
William John
Nadia Chouaki
Annamaria H. Zimmermann
Carla Visseren-grul
Cesare Gridelli
S. Gerardo Hospital
Monza Cesare
Moscati Hospital
Avellino Italy
Centre Hospitalier Regional
Tarini Prasad Sahoo
Jawaharlal Nehru
William John
Annamaria H
Carla Visseren-grul
Eli Lilly

October 2016

Houten, the Netherlands. Published online ahead of print at www.jco.org on July 8, 2013. Supported b...

Multinational Randomized Phase III Trial With or Without Consolidation Chemotherapy Using Docetaxel and Cisplatin After Concurrent Chemoradiation in Inoperable Stage III Non-Small-Cell Lung Cancer: KCSG-LU05-04

이창걸

August 2015

Purpose: To determine the efficacy of consolidation chemotherapy (CC) with docetaxel and cisplatin ...

Three-Year Follow-Up of a Randomized Phase II Trial on Refinement of Early-Stage NSCLC Adjuvant Chemotherapy with Cisplatin and Pemetrexed versus Cisplatin and Vinorelbine (the TREAT Study)

Kreuter, Michael
Vansteenkiste, Johan
Fischer, Jürgen R
Eberhardt, Wilfried E
Zabeck, Heike
Kollmeier, Jens
Serke, Monika
Frickhofen, Norbert
Reck, Martin
Engel-Riedel, Walburga
Neumann, Silke
Thomeer, Michiel
Schumann, Christian
De Leyn, Paul
Graeter, Thomas
Stamatis, Georgios
Griesinger, Frank

January 2016

Adjuvant chemotherapy in non-small cell lung cancer (NSCLC) improves survival but is associated with...

Final results from a Phase II study of pemetrexed and cisplatin with concurrent thoracic radiation after Pem-Cis induction in patients with unresectable locally advanced non-squamous non-small cell lung cancer (NSCLC)

Garrido, Pilar
Engel-Riedel, Walburga
Serke, Monika
Giraud, Philippe
Ricardi, Umberto
Vallejo, Carmen
Visseren-Grul, Carla
Ameryckx, Sophie
Soldatenkova, Victoria
Chouaki, Nadia
Novello, Silvia

May 2015

AbstractObjectivesThis single-arm multicenter Phase II study investigated the efficacy and safety of...

Original Article A Phase II Study of Cisplatin and Irinotecan As Induction Chemotherapy Followed by Concomitant Thoracic Radiotherapy with Weekly Low-dose Irinotecan in Unresectable, Stage III,

Non-small Cell
Lung Cancer Jcog
Koji Takeda
Shunichi Negoro
Masahiro Tanaka
Haruhiko Fukuda
Kazuhiko Nakagawa
Masaaki Kawahara
Hiroshi Semba
Shinzoh Kudoh
Toshiyuki Sawa
Nagahiro Saijo

January 2010

Objective: It is important to identify optimal regimens of cisplatin-based, third-generation che-mot...

Phase 2 Study of Pemetrexed Plus Carboplatin, or Pemetrexed Plus Cisplatin with Concurrent Radiation Therapy Followed by Pemetrexed Consolidation in Patients with Favorable-Prognosis Inoperable Stage IIIA/B Non–Small-Cell Lung Cancer

Choy, Hak
Schwartzberg, Lee S.
Dakhil, Shaker R.
Garon, Edward B.
Gerber, David E.
Choksi, Janak K.
Govindan, Ramaswamy
Peng, Guangbin
Koustenis, Andrew
Treat, Joseph
Obasaju, Coleman

October 2013

IntroductionThere is no consensus chemotherapy regimen with concurrent radiotherapy (RT) for inopera...

PROCLAIM: Randomized Phase III Trial of Pemetrexed-Cisplatin or Etoposide-Cisplatin Plus Thoracic Radiation Therapy Followed by Consolidation Chemotherapy in Locally Advanced Nonsquamous Non-Small-Cell Lung Cancer

Senan, Suresh
Brade, Anthony
Wang, Lu-Hua
Vansteenkiste, Johan
Dakhil, Shaker
Biesma, Bonne
Martinez Aguillo, Maite
Aerts, Joachim
Govindan, Ramaswamy
Rubio-Viqueira, Belén
Lewanski, Conrad
Gandara, David
Choy, Hak
Mok, Tony
Hossain, Anwar
Iscoe, Neill
Treat, Joseph
Koustenis, Andrew
San Antonio, Bélen
Chouaki, Nadia
Vokes, Everett

March 2016

The phase III PROCLAIM study evaluated overall survival (OS) of concurrent pemetrexed-cisplatin and ...

Chemotherapy in non-small cell lung cancer: opportunities for advancement

Mani Akhtari
Eric H. Bernicker
Bin S. Teh

June 2016

Abstract Locally advanced non-small cell lung cancer (NSCLC) continues to be a challenging disease t...

Three-Year Follow-Up of a Randomized Phase II Trial on Refinement of Early-Stage NSCLC Adjuvant Chemotherapy with Cisplatin and Pemetrexed versus Cisplatin and Vinorelbine (the TREAT Study)

Kreuter, Michael
Vansteenkiste, Johan
Fischer, Jürgen R
Eberhardt, Wilfried E
Zabeck, Heike
Kollmeier, Jens
Serke, Monika
Frickhofen, Norbert
Reck, Martin
Engel-Riedel, Walburga
Neumann, Silke
Thomeer, Michiel
Schumann, Christian
De Leyn, Paul
Graeter, Thomas
Stamatis, Georgios
Griesinger, Frank

January 2016

Adjuvant chemotherapy in non-small cell lung cancer (NSCLC) improves survival but is associated with...

Treatment rationale and study design for a phase III, double-blind, placebo-controlled study of maintenance pemetrexed plus best supportive care versus best supportive care immediately following induction treatment with pemetrexed plus cisplatin for advanced nonsquamous non-small cell lung cancer.

Paz-Ares, Luis G.
Altug, Sedat.
Vaury, Alexandra T.
Jaime, Jesús C.
Russo, Francesca.
Visseren-Grul, Carla.

March 2010

TRIAL REGISTRATION: Trial Registry: Clinicaltrials.gov REGISTRATION NUMBER: NCT00789373 TRIAL ABBREV...

Treatment rationale and study design for a phase III, double-blind, placebo-controlled study of maintenance pemetrexed plus best supportive care versus best supportive care immediately following induction treatment with pemetrexed plus cisplatin for advanced nonsquamous non-small cell lung cancer.

Paz-Ares, Luis G.
Altug, Sedat.
Vaury, Alexandra T.
Jaime, Jesús C.
Russo, Francesca.
Visseren-Grul, Carla.

March 2010

TRIAL REGISTRATION: Trial Registry: Clinicaltrials.gov REGISTRATION NUMBER: NCT00789373 TRIAL ABBREV...

Treatment rationale and study design for a phase III, double-blind, placebo-controlled study of maintenance pemetrexed plus best supportive care versus best supportive care immediately following induction treatment with pemetrexed plus cisplatin for advanced nonsquamous non-small cell lung cancer.

Paz-Ares, Luis G.
Altug, Sedat.
Vaury, Alexandra T.
Jaime, Jesús C.
Russo, Francesca.
Visseren-Grul, Carla.

March 2010

TRIAL REGISTRATION: Trial Registry: Clinicaltrials.gov REGISTRATION NUMBER: NCT00789373 TRIAL ABBREV...

Phase III Study of Surgery Versus Definitive Concurrent Chemoradiotherapy Boost in Patients With Resectable Stage IIIA(N2) and Selected IIIB Non-Small-Cell Lung Cancer After Induction Chemotherapy and Concurrent Chemoradiotherapy (ESPATUE)

Eberhardt, Wilfried Ernst Erich
Pöttgen, Christoph
Gauler, Thomas Christoph
Friedel, Godehard
Veit, Stefanie
Heinrich, Vanessa
Welter, Stefan
Budach, Wilfried
Spengler, Werner
Kimmich, Martin
Fischer, Berthold
Schmidberger, Heinz
De Ruysscher, Dirk
Belka, Claus
Cordes, Sebastian
Hepp, Rodrigo
Lütke-Brintrup, Diana
Lehmann, Nils
Schuler, Martin
Jöckel, Karl-Heinz
Stamatis, Georgios
Stuschke, Martin

December 2015

Concurrent chemoradiotherapy with or without surgery are options for stage IIIA(N2) non-small-cell l...

A phase III randomised study comparing concomitant radiochemotherapy with cisplatin and docetaxel as induction versus consolidation treatment in patients with locally advanced unresectable non-small cell lung cancer

Sculier, Jean-Paul
Giner, Vicente
Paesmans, Marianne
Leclercq, Nathalie
Van Houtte, Paul
Lafitte, Jean-Jacques
Berghmans, Thierry
Meert, Anne-Pascale
Scherpereel, Arnaud
Roelandts, Martine
Van Cutsem, O
Colinet, Benoît
Bonduelle, Y.

March 2018

Objectives: To assess if induction radiochemotherapy followed by consolidation chemotherapy (arm A) ...

Phase II Study of Pemetrexed and Cisplatin, with Chest Radiotherapy Followed by Docetaxel in Patients with Stage III Non-small Cell Lung Cancer

Gadgeel, Shirish M.
Ruckdeschel, John C.
Patel, Bhaumik B.
Wozniak, Antoinette
Konski, Andre
Valdivieso, Manuel
Hackstock, Deborah
Chen, Wei
Belzer, Kimberly
Burger, Angelika M.
Marquette, Lauren
Turrisi, Andrew

May 2011

BackgroundPemetrexed has emerged as one of the most active agents for the treatment of patients with...

PARAMOUNT: Final Overall Survival Results of the Phase III Study of Maintenance Pemetrexed Versus Placebo Immediately After Induction Treatment With Pemetrexed Plus Cisplatin for Advanced Nonsquamous Non–Small-Cell Lung

Luis G. Paz-ares
Mircea Dediu
Michael Thomas
Jean-louis Pujol
Paolo Bidoli
Olivier Molinier
Tarini Prasad Sahoo
Eckart Laack
Martin Reck
Symantha Melemed
William John
Nadia Chouaki
Annamaria H. Zimmermann
Carla Visseren-grul
Cesare Gridelli
S. Gerardo Hospital
Monza Cesare
Moscati Hospital
Avellino Italy
Centre Hospitalier Regional
Tarini Prasad Sahoo
Jawaharlal Nehru
William John
Annamaria H
Carla Visseren-grul
Eli Lilly

October 2016

Houten, the Netherlands. Published online ahead of print at www.jco.org on July 8, 2013. Supported b...

Multinational Randomized Phase III Trial With or Without Consolidation Chemotherapy Using Docetaxel and Cisplatin After Concurrent Chemoradiation in Inoperable Stage III Non-Small-Cell Lung Cancer: KCSG-LU05-04

이창걸

August 2015

Purpose: To determine the efficacy of consolidation chemotherapy (CC) with docetaxel and cisplatin ...

Three-Year Follow-Up of a Randomized Phase II Trial on Refinement of Early-Stage NSCLC Adjuvant Chemotherapy with Cisplatin and Pemetrexed versus Cisplatin and Vinorelbine (the TREAT Study)

Kreuter, Michael
Vansteenkiste, Johan
Fischer, Jürgen R
Eberhardt, Wilfried E
Zabeck, Heike
Kollmeier, Jens
Serke, Monika
Frickhofen, Norbert
Reck, Martin
Engel-Riedel, Walburga
Neumann, Silke
Thomeer, Michiel
Schumann, Christian
De Leyn, Paul
Graeter, Thomas
Stamatis, Georgios
Griesinger, Frank

January 2016

Adjuvant chemotherapy in non-small cell lung cancer (NSCLC) improves survival but is associated with...

Final results from a Phase II study of pemetrexed and cisplatin with concurrent thoracic radiation after Pem-Cis induction in patients with unresectable locally advanced non-squamous non-small cell lung cancer (NSCLC)

Garrido, Pilar
Engel-Riedel, Walburga
Serke, Monika
Giraud, Philippe
Ricardi, Umberto
Vallejo, Carmen
Visseren-Grul, Carla
Ameryckx, Sophie
Soldatenkova, Victoria
Chouaki, Nadia
Novello, Silvia

May 2015

AbstractObjectivesThis single-arm multicenter Phase II study investigated the efficacy and safety of...

Original Article A Phase II Study of Cisplatin and Irinotecan As Induction Chemotherapy Followed by Concomitant Thoracic Radiotherapy with Weekly Low-dose Irinotecan in Unresectable, Stage III,

Non-small Cell
Lung Cancer Jcog
Koji Takeda
Shunichi Negoro
Masahiro Tanaka
Haruhiko Fukuda
Kazuhiko Nakagawa
Masaaki Kawahara
Hiroshi Semba
Shinzoh Kudoh
Toshiyuki Sawa
Nagahiro Saijo

January 2010

Objective: It is important to identify optimal regimens of cisplatin-based, third-generation che-mot...

Phase 2 Study of Pemetrexed Plus Carboplatin, or Pemetrexed Plus Cisplatin with Concurrent Radiation Therapy Followed by Pemetrexed Consolidation in Patients with Favorable-Prognosis Inoperable Stage IIIA/B Non–Small-Cell Lung Cancer

Choy, Hak
Schwartzberg, Lee S.
Dakhil, Shaker R.
Garon, Edward B.
Gerber, David E.
Choksi, Janak K.
Govindan, Ramaswamy
Peng, Guangbin
Koustenis, Andrew
Treat, Joseph
Obasaju, Coleman

October 2013

IntroductionThere is no consensus chemotherapy regimen with concurrent radiotherapy (RT) for inopera...

PROCLAIM: Randomized Phase III Trial of Pemetrexed-Cisplatin or Etoposide-Cisplatin Plus Thoracic Radiation Therapy Followed by Consolidation Chemotherapy in Locally Advanced Nonsquamous Non-Small-Cell Lung Cancer

Abstract

Extracted data

PROCLAIM: Randomized Phase III Trial of Pemetrexed-Cisplatin or Etoposide-Cisplatin Plus Thoracic Radiation Therapy Followed by Consolidation Chemotherapy in Locally Advanced Nonsquamous Non-Small-Cell Lung Cancer

Abstract

Extracted data

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