A weakly acidic solution containing deoxycholic acid induces esophageal epithelial apoptosis and impairs integrity in an in vivo perfusion rabbit model

Impaired esophageal mucosal integrity may be an important contributor in the pathophysiology of GERD. Nevertheless, the effect of potentially harmful agents on epithelial integrity is mainly evaluated in vitro, for a short period of time and the possible induction of epithelial apoptosis has been neglected.status: publishe