CD36 deficiency blunts effects of diet on regulatory T cells in murine gonadal adipose tissue and mesenteric lymph nodes

The effect of cluster of differentiation (CD)36 on regulatory T cells (Treg) was investigated in gonadal (GN) adipose tissues and mesenteric lymph nodes (MLN) of wild-type (WT) and CD36 deficient (CD36−/−) mice kept on standard fat (SFD, lean) or on high fat diet (HFD, obese). GN adipose tissue mass was smaller, but MLN size larger for obese CD36−/− versus obese WT mice. Overall, the reduction of Treg cells in GN adipose tissue and MLN after a HFD is much more prominent in WT than CD36−/− mice. Moreover, CD36−/− mice may be protected against obesity-related chronic inflammation.publisher: Elsevier articletitle: CD36 deficiency blunts effects of diet on regulatory T cells in murine gonadal adipose tissue and mesenteric lymph nodes journaltitle: Cellular Immunology articlelink: http://dx.doi.org/10.1016/j.cellimm.2015.08.006 content_type: article copyright: Copyright © 2015 Elsevier Inc. All rights reserved.status: publishe