Cationic Rhodium (III)-Catalyzed Direct C-2 Carboxamidation of Indoles with Isocyanates via C-H Bond Functionalization

Xu, Jun
Sharma, Nandini
Sharma, Upendra
Li, Zhenghua
Song, Gonghua
Van der Eycken, Erik

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Publication date

August 2015

DOI

10.1002/adsc.201500109

Publisher

Wiley

Journal

Advanced Synthesis & Catalysis

Abstract

© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. A pentamethylcyclopentadienylrhodium(III)-catalyzed regioselective synthesis of indole-2-carboxamides is described employing N-pyrimidylindoles and isocyanates as coupling partners via C-H functionalization. A wide variety of indole-2-carboxamides can be synthesized via this method under relatively mild conditions with broad functional group tolerance. The effect of various directing group on this transformation was also studied, unveiling the pyrimidyl group as an easily installable and removable directing group.status: publishe

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Cationic Rhodium (III)-Catalyzed Direct C-2 Carboxamidation of Indoles with Isocyanates via C-H Bond Functionalization

Abstract

Extracted data

Cationic Rhodium (III)-Catalyzed Direct C-2 Carboxamidation of Indoles with Isocyanates via C-H Bond Functionalization

Abstract

Extracted data

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