Geographic and temporal trends in the molecular epidemiology and genetic mechanisms of transmitted HIV-1 drug resistance: an individual-patient- and sequence-level meta-analysis
- Rhee, Soo-Yon
- Blanco, Jose Luis
- Jordan, Michael R
- Taylor, Jonathan
- Lemey, Philippe
- Varghese, Vici
- Hamers, Raph L
- Bertagnolio, Silvia
- Rinke de Wit, Tobias F
- Aghokeng, Avelin F
- Albert, Jan
- Avi, Radko
- Avila-Rios, Santiago
- Bessong, Pascal O
- Brooks, James I
- Boucher, Charles AB
- Brumme, Zabrina L
- Busch, Michael P
- Bussmann, Hermann
- Chaix, Marie-Laure
- Chin, Bum Sik
- D'Aquin, Toni T
- De Gascun, Cillian F
- Derache, Anne
- Descamps, Diane
- Deshpande, Alaka K
- Djoko, Cyrille F
- Eshleman, Susan H
- Fleury, Herve
- Frange, Pierre
- Fujisaki, Seiichiro
- Harrigan, P Richard
- Hattori, Junko
- Holguin, Africa
- Hunt, Gillian M
- Ichimura, Hiroshi
- Kaleebu, Pontiano
- Katzenstein, David
- Kiertiburanakul, Sasisopin
- Kim, Jerome H
- Kim, Sung Soon
- Li, Yanpeng
- Lutsar, Irja
- Morris, Lynn
- Ndembi, Nicaise
- Ng, Kee Peng
- Paranjape, Ramesh S
- Poljak, Mario
- Price, Matt A
- Ragonnet-Cronin, Manon L
- Reyes-Terán, Gustavo
- Rolland, Morgane
- Sirivichayakul, Sunee
- Smith, Davey M
- Soares, Marcelo A
- Soriano, Vincent V
- Ssemwanga, Deogratius
- Stanojevic, Maja
- Stefani, Mariane A
- Sugiura, Wataru
- Sungkanuparph, Somnuek
- Tanuri, Amilcar
- Tee, Kok Keng
- Truong, Hong-Ha M
- van de Vijver, David AMC
- Vidal, Nicole
- Yang, Chunfu
- Yang, Rongge
- Yebra, Gonzalo
- Ioannidis, John PA
- Vandamme, Anne-Mieke
- Shafer, Robert W
Publication date
April 2015
DOI Publisher
Public Library of Science (PLoS) Journal
PLoS MedicineAbstract
Regional and subtype-specific mutational patterns of HIV-1 transmitted drug resistance (TDR) are essential for informing first-line antiretroviral (ARV) therapy guidelines and designing diagnostic assays for use in regions where standard genotypic resistance testing is not affordable. We sought to understand the molecular epidemiology of TDR and to identify the HIV-1 drug-resistance mutations responsible for TDR in different regions and virus subtypes.status: publishe
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