At the primary level small heat shock proteins are commonly described as a conserved α-crystallin domain flanked by regions that have disparate sequence content. While this holds true when analysing simple pairwise alignments, it belittles the importance of these N-terminal and C-terminal extensions. Careful examination of their sequences,combined with an improved understanding of the structure and activity of these proteins, yields an alternative view where the N- and C-terminal arms play an important role in function. In this chapter we shall describe the current understanding of these two regions and highlight that they both demonstrate structural and functional properties that are highly conserved across all kingdoms of life.status: acc...
HSPB6 is a member of the human small heat shock protein (sHSP) family, a conserved group of molecula...
Several small heat shock proteins contain a well conserved α-crystallin domain, flanked by an N...
HSPB6 is a member of the human small heat shock protein (sHSP) family, a conserved group of molecula...
At the primary level small heat shock proteins are commonly described as a conserved α-crystallin do...
Small heat shock proteins (sHsps) are molecular chaperones involved in maintaining protein homeostas...
Small heat-shock proteins (sHsps), such as αB-crystallin, are one of the major classes of molecular ...
Small heat-shock proteins (sHsps), such as αB-crystallin, are one of the major classes of molecular ...
Small heat-shock proteins (sHsps), such as αB-crystallin, are one of the major classes of molecular ...
Small heat shock proteins (sHSPs) are abundantly present in many different organisms at elevated tem...
Although the N-terminal domain of vertebrate small heat shock proteins (sHsp) is poorly conserved, i...
Small heat shock proteins (sHsps) are a diverse family evolved from ancient stress proteins that are...
BACKGROUND: Small Heat Shock Proteins (sHSPs) are chaperone-like proteins involved in the prevention...
Small heat shock proteins (sHsps) are intracellular molecular chaperones that prevent the aggregatio...
Small heat shock proteins (sHsps) are molecular chaperones that bind unfolding proteins and confer c...
The α-crystallin domain (ACD) is the hallmark of a diverse family of small heat shock proteins (sHsp...
HSPB6 is a member of the human small heat shock protein (sHSP) family, a conserved group of molecula...
Several small heat shock proteins contain a well conserved α-crystallin domain, flanked by an N...
HSPB6 is a member of the human small heat shock protein (sHSP) family, a conserved group of molecula...
At the primary level small heat shock proteins are commonly described as a conserved α-crystallin do...
Small heat shock proteins (sHsps) are molecular chaperones involved in maintaining protein homeostas...
Small heat-shock proteins (sHsps), such as αB-crystallin, are one of the major classes of molecular ...
Small heat-shock proteins (sHsps), such as αB-crystallin, are one of the major classes of molecular ...
Small heat-shock proteins (sHsps), such as αB-crystallin, are one of the major classes of molecular ...
Small heat shock proteins (sHSPs) are abundantly present in many different organisms at elevated tem...
Although the N-terminal domain of vertebrate small heat shock proteins (sHsp) is poorly conserved, i...
Small heat shock proteins (sHsps) are a diverse family evolved from ancient stress proteins that are...
BACKGROUND: Small Heat Shock Proteins (sHSPs) are chaperone-like proteins involved in the prevention...
Small heat shock proteins (sHsps) are intracellular molecular chaperones that prevent the aggregatio...
Small heat shock proteins (sHsps) are molecular chaperones that bind unfolding proteins and confer c...
The α-crystallin domain (ACD) is the hallmark of a diverse family of small heat shock proteins (sHsp...
HSPB6 is a member of the human small heat shock protein (sHSP) family, a conserved group of molecula...
Several small heat shock proteins contain a well conserved α-crystallin domain, flanked by an N...
HSPB6 is a member of the human small heat shock protein (sHSP) family, a conserved group of molecula...