Synthesis and anti-HIV-1 activity of 1-[omega-(phenoxy)alkyl and -alkenyl]Uracil derivatives
- Paramonova, MP
- Babkov, DA
- Valuev-Elliston, VT
- Ivanov, AV
- Kochetkov, SN
- Pannecouque, Christophe
- Ozerov, AA
- Balzarini, Jan
- Novikov, MS
Publication date
December 2013
DOI Publisher
Springer Science and Business Media LLC Journal
Pharmaceutical Chemistry JournalAbstract
1-[ω-(Phenoxy)alkyl and -alkenyl]uracil derivatives were synthesized via condensation of equimolar amounts of 2,4-bis(trimethylsilyloxy)pyrimidine and 1-halo-ω-(phenoxy)alkane or -alkene in order to discover new non-nucleoside inhibitors of HIV-1 reverse transcriptase. Their anti-HIV-1 activity was studied in CEM-cell culture and against HIV-1 reverse transcriptase. It was found that several compounds exhibited marked activity. © 2013 Springer Science+Business Media New York.status: publishe
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