Multicomponent T2 relaxation complements diffusion MRI in the characterization of T2 hyperintensities related with Neurofibromatosis type 1

In Neurofibromatosis type 1 (NF1), socalled “unidentified bright objects“(UBOs), have been shown to correlate with learning difficulties[1]. Although the exact nature of UBOs is not known, one hypothesis is vacuolization of the myelin sheath and astroglial cell proliferation. The present in vivo study assesses the microstructure of UBOs using diffusion kurtosis imaging (DKI) and myelin water imaging (MWI).status: publishe