Op zoek naar nieuwe virulentiefactoren van de vispathogeen Vibrio anguillarum

Fish diseases pose a universal threat to the larviculture, aquaculture,ornamental fish industry, and public health. They can be caused by manyorganisms, including bacteria, fungi, viruses, and protozoa. Vibrio anguillarum , for example, is the causative agent of vibriosis, a deadly hemorrhagic septicemic disease affecting various marine and fresh/brackish water fish, bivalves and crustaceans. In both the larviculture and aquaculture, this disease is responsible for severe economic losses worldwide because of its high morbidity and mortality rate.During the last decades, substantial research activity has been carriedout in order to unravel the virulence mechanisms of this pathogen, to devise rapid detection and identification techniques, and to develop effective disease prevention strategies. Nevertheless, the virulence mechanisms of this pathogen and the virulence factors critical for pathogenesisare still insufficiently known. The major challenge of this research was to increase the understanding of the pathogenicity of V. anguillarum and to develop a DNA-based multiplex detection system which issuitable to implement identified virulence markers in a later stage.nrpages: 153status: publishe