The Role of LOX and LOXL2 in Scar Formation After Glaucoma Surgery
- Van Bergen, Tine
- Marshall, Derek
- Van de Veire, Sara
- Vandewalle, Evelien
- Moons, Lieve
- Herman, Jean
- Smith, Victoria
- Stalmans, Ingeborg
Publication date
August 2013
DOI Publisher
Association for Research in Vision and Ophthalmology (ARVO) Journal
Investigative Ophthalmology & Visual ScienceAbstract
The aim of this study was to elucidate the role of lysyl oxidase (LOX) and lysyl oxidase like (LOXL) 2 in pathologic wound healing after glaucoma surgery. We therefore investigated the expression of LOX and LOXL2 and evaluated the therapeutic potential of anti-LOX (GS-639556, formerly M64) and anti-LOXL2 (GS-607601, formerly AB0023) antibodies in a rabbit model of glaucoma trabeculectomy.status: publishe
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