Carboxypeptidase M in apoptosis, adipogenesis and cancer

  • Denis, Catherine J
  • Deiteren, Kathleen
  • Hendriks, Dirk
  • Proost, Paul
  • Lambeir, Anne-Marie
Publication date
February 2013
Publisher
Elsevier BV
Journal
Clinica Chimica Acta

Abstract

This review covers carboxypeptidase M (CPM) research that appeared in the literature since 2009. The focus is on aspects that are new or interesting from a clinical perspective. Available research tools are discussed as well as their pitfalls and limitations. Evidence is provided to suggest the potential involvement of CPM in apoptosis, adipogenesis and cancer. This evidence derives from the expression pattern of CPM and its putative substrates in cells and tissues. In recent years CPM emerged as a potential cancer biomarker, in well differentiated liposarcoma where the CPM gene is co-amplified with the oncogene MDM2; and in lung adenocarcinoma where coexpression with EGFR correlates with poor prognosis. The available data call for extended...

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