This review covers carboxypeptidase M (CPM) research that appeared in the literature since 2009. The focus is on aspects that are new or interesting from a clinical perspective. Available research tools are discussed as well as their pitfalls and limitations. Evidence is provided to suggest the potential involvement of CPM in apoptosis, adipogenesis and cancer. This evidence derives from the expression pattern of CPM and its putative substrates in cells and tissues. In recent years CPM emerged as a potential cancer biomarker, in well differentiated liposarcoma where the CPM gene is co-amplified with the oncogene MDM2; and in lung adenocarcinoma where coexpression with EGFR correlates with poor prognosis. The available data call for extended...
Abstract Background The incidence and mortality of invasive breast cancer (IBC) are increasing annua...
Thesis (M.A.)--Boston University PLEASE NOTE: Boston University Libraries did not receive an Author...
Breast cancer is the commonest malignancy of women and with its incidence on the rise, the need to i...
Carboxypeptidase M (CPM) targets the basic amino acids arginine and lysine present at the C-terminus...
Carboxypeptidase M (CPM) targets the basic amino acids arginine and lysine present at the C-terminus...
Cancer, group of diseases characterized by an uncontrolled cell growth, represents one of the great ...
Carboxypeptidase M (CPM) targets the basic amino acids arginine and lysine present at the C-terminus...
Recent research focused on prolonged survival has suggested that carboxypeptidase A4 (CPA4) plays a ...
Chromatin-modifying enzymes, especially protein arginine methyltransferases (PRMTs), have been ident...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, with a high mortality rat...
[[abstract]]Carboxypeptidase E (CPE), a prohormone processing enzyme, is a 476- amino acid protein w...
Carboxypeptidase O (CPO) cleaves acidic and polar C-terminal amino acids of peptides and proteins; h...
Carboxypeptidase O (CPO) is a member of the M14 family of metallocarboxypeptidases with a preference...
Carboxypeptidase O (CPO) is a member of the M14 family of metallocarboxypeptidases with a preference...
Adipose tissue expansion occurs through a combination of hypertrophy of existing adipocytes and gene...
Abstract Background The incidence and mortality of invasive breast cancer (IBC) are increasing annua...
Thesis (M.A.)--Boston University PLEASE NOTE: Boston University Libraries did not receive an Author...
Breast cancer is the commonest malignancy of women and with its incidence on the rise, the need to i...
Carboxypeptidase M (CPM) targets the basic amino acids arginine and lysine present at the C-terminus...
Carboxypeptidase M (CPM) targets the basic amino acids arginine and lysine present at the C-terminus...
Cancer, group of diseases characterized by an uncontrolled cell growth, represents one of the great ...
Carboxypeptidase M (CPM) targets the basic amino acids arginine and lysine present at the C-terminus...
Recent research focused on prolonged survival has suggested that carboxypeptidase A4 (CPA4) plays a ...
Chromatin-modifying enzymes, especially protein arginine methyltransferases (PRMTs), have been ident...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, with a high mortality rat...
[[abstract]]Carboxypeptidase E (CPE), a prohormone processing enzyme, is a 476- amino acid protein w...
Carboxypeptidase O (CPO) cleaves acidic and polar C-terminal amino acids of peptides and proteins; h...
Carboxypeptidase O (CPO) is a member of the M14 family of metallocarboxypeptidases with a preference...
Carboxypeptidase O (CPO) is a member of the M14 family of metallocarboxypeptidases with a preference...
Adipose tissue expansion occurs through a combination of hypertrophy of existing adipocytes and gene...
Abstract Background The incidence and mortality of invasive breast cancer (IBC) are increasing annua...
Thesis (M.A.)--Boston University PLEASE NOTE: Boston University Libraries did not receive an Author...
Breast cancer is the commonest malignancy of women and with its incidence on the rise, the need to i...