Cyclin D1-negative mantle cell lymphomas (MCL) are not well characterized, in part due to the difficulties in their recognition. SOX11 has been recently identified as a reliable biomarker of MCL, also expressed in the cyclin D1-negative variant. We investigated 40 lymphomas with MCL morphology and immunophenotype, negative for cyclin D1 expression/t(11;14)(q13;q32) but SOX11-positive. These tumors presented clinically with generalized lymphadenopathy, advanced stage, and had a poor outcome (5-year overall survival 48%). Chromosomal rearrangements of the CCND2 locus were detected in 55% of the cases, with an IG gene as partner in 18/22 cases, in particular with light chains (10 IGK@, 5 IGL@). No mutations in the phosphorylation motifs of CCN...
At the molecular level mantle cell lymphoma (MCL) is characterized by a specific translocation t(11;...
Mantle cell lymphoma (MCL) is a rare but unique subtype of non-Hodgkin B-cell lymphoma that is molec...
International audienceMantle cell lymphoma (MCL) is a lymphoproliferative disorder characterized by ...
Cyclin D1 (CCND1) protein overexpression and/or the t(11;14)(q13;q32) translocation are the pathogno...
Cyclin D1 overexpression is believed to be essential in the pathogenesis of mantle cell lymphoma (MC...
Cyclin D1+ mantle cell lymphoma (MCL) is molecularly characterized by the t(11;14)(q13;q32) or rear...
BACKGROUND: Cyclin D1-negative mantle cell lymphoma is difficult to distinguish from other small B-c...
Mantle cell lymphoma (MCL) is characterized by the t(11;14)(q13;q32) translocation resulting in over...
Mantle cell lymphoma (MCL) is a clinically aggressive B-cell lymphoma associated with 11q13 transloc...
Purpose To compare the genetic relationship between cyclin D1 - positive and cyclin D1 - negative ma...
Mantle cell lymphoma (MCL) is characterized by the t(11;14)(q13;q32) translocation resulting in over...
Mantle cell lymphomas (MCLs) are the prototypic B-cell non-Hodgkin lymphomas defined by cyclin D1 ge...
Mantle cell lymphoma (MCL) is a distinct subentity of non-Hodgkin lymphoma, characterized by the chr...
Mantle cell lymphoma (MCL) is characterized by the t(11;14)(q13;q32) translocation resulting in over...
SOX11 is a transcription factor that is normally expressed in the fetal brain and has also been dete...
At the molecular level mantle cell lymphoma (MCL) is characterized by a specific translocation t(11;...
Mantle cell lymphoma (MCL) is a rare but unique subtype of non-Hodgkin B-cell lymphoma that is molec...
International audienceMantle cell lymphoma (MCL) is a lymphoproliferative disorder characterized by ...
Cyclin D1 (CCND1) protein overexpression and/or the t(11;14)(q13;q32) translocation are the pathogno...
Cyclin D1 overexpression is believed to be essential in the pathogenesis of mantle cell lymphoma (MC...
Cyclin D1+ mantle cell lymphoma (MCL) is molecularly characterized by the t(11;14)(q13;q32) or rear...
BACKGROUND: Cyclin D1-negative mantle cell lymphoma is difficult to distinguish from other small B-c...
Mantle cell lymphoma (MCL) is characterized by the t(11;14)(q13;q32) translocation resulting in over...
Mantle cell lymphoma (MCL) is a clinically aggressive B-cell lymphoma associated with 11q13 transloc...
Purpose To compare the genetic relationship between cyclin D1 - positive and cyclin D1 - negative ma...
Mantle cell lymphoma (MCL) is characterized by the t(11;14)(q13;q32) translocation resulting in over...
Mantle cell lymphomas (MCLs) are the prototypic B-cell non-Hodgkin lymphomas defined by cyclin D1 ge...
Mantle cell lymphoma (MCL) is a distinct subentity of non-Hodgkin lymphoma, characterized by the chr...
Mantle cell lymphoma (MCL) is characterized by the t(11;14)(q13;q32) translocation resulting in over...
SOX11 is a transcription factor that is normally expressed in the fetal brain and has also been dete...
At the molecular level mantle cell lymphoma (MCL) is characterized by a specific translocation t(11;...
Mantle cell lymphoma (MCL) is a rare but unique subtype of non-Hodgkin B-cell lymphoma that is molec...
International audienceMantle cell lymphoma (MCL) is a lymphoproliferative disorder characterized by ...