New anti-HIV aptamers based on tetra-end-linked DNA G-quadruplexes: effect of the base sequence on anti-HIV activity
- D'Atri, Valentina
- Oliviero, Giorgia
- Amato, Jussara
- Borbone, Nicola
- D'Errico, Stefano
- Mayol, Luciano
- Piccialli, Vincenzo
- Haider, Shozeb
- Hoorelbeke, Bart
- Balzarini, Jan
- Piccialli, Gennaro
Publication date
October 2012
DOI Publisher
Royal Society of Chemistry (RSC) Journal
Chemical CommunicationsAbstract
This communication reports on the synthesis and biophysical, biological and SAR studies of a small library of new anti-HIV aptamers based on the tetra-end-linked G-quadruplex structure. The new aptamers showed EC(50) values against HIV-1 in the range of 0.04-0.15 μM as well as affinities for the HIV-1 gp120 envelope in the same order of magnitude.status: publishe
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