Nine newly 6-cynao-2-naphthyl substituted diarylpyrimidines (DAPY) were synthesized as non-nucleoside reverse transcriptase inhibitors on the basis of our previous work. The antiviral and cytotoxicity evaluation indicated that these compounds displayed strong activity against wild-type HIV-1 at nanomolar concentrations with selectivity index SI greater than 23 779. The most active compounds 3c and 3e exhibited activity against the double mutant (103N+181C) strains at an EC(50) of 0.16 and 0.15muM, and were more activity than that of efavirenz.status: publishe
A series of novel diarylpyrimidines (DAPYs) with a ketone hydrazone substituent on the methylene lin...
A series of new DAPY-DPEs hybrids, combined the important pharmacophores of DAPYs and DPEs, has been...
By means of structure-based molecular hybridization strategy, a series of novel diarylpyri(mi)dine d...
This paper reports the synthesis and the antiviral properties of new diarylpyrimidine (DAPY) compoun...
As a continuation of our efforts to discover and develop "me-better" drugs of DAPYs, novel diarylpyr...
Antiviral agents: A series of CN-CH2-DAPY analogues were identified as novel non-nucleoside reverse ...
The synthesis and anti-HIV-1 activity of a series of diarylpyrimidines (DAPYs) are described. Severa...
A series of new diarylpyrimidines (DAPYs) characterized by a halogen atom on the methylene linker be...
A series of novel 4,6-diarylpyrimidines (4,6-DAPY) and diarylbenzenes (DABE) compounds were synthesi...
To improve the conformational flexibility and positional adaptability of the traditional diarylpyrim...
A novel series of diarylpyrimidine (DAPY) derivatives bearing the biphenyl motif with multiple subst...
30 new analogues of diarylpyrimidines were synthesized for further structural modifications, involvi...
Guided by crystal structures of HIV-1 RT/DAPY complex and molecular modeling studies, a series of no...
This paper reports the synthesis and antiviral evaluation of a series of non-nucleoside reverse tran...
A series of novel diarylpyrimidine analogues featuring a hydroxyiminomethyl group between the pyrimi...
A series of novel diarylpyrimidines (DAPYs) with a ketone hydrazone substituent on the methylene lin...
A series of new DAPY-DPEs hybrids, combined the important pharmacophores of DAPYs and DPEs, has been...
By means of structure-based molecular hybridization strategy, a series of novel diarylpyri(mi)dine d...
This paper reports the synthesis and the antiviral properties of new diarylpyrimidine (DAPY) compoun...
As a continuation of our efforts to discover and develop "me-better" drugs of DAPYs, novel diarylpyr...
Antiviral agents: A series of CN-CH2-DAPY analogues were identified as novel non-nucleoside reverse ...
The synthesis and anti-HIV-1 activity of a series of diarylpyrimidines (DAPYs) are described. Severa...
A series of new diarylpyrimidines (DAPYs) characterized by a halogen atom on the methylene linker be...
A series of novel 4,6-diarylpyrimidines (4,6-DAPY) and diarylbenzenes (DABE) compounds were synthesi...
To improve the conformational flexibility and positional adaptability of the traditional diarylpyrim...
A novel series of diarylpyrimidine (DAPY) derivatives bearing the biphenyl motif with multiple subst...
30 new analogues of diarylpyrimidines were synthesized for further structural modifications, involvi...
Guided by crystal structures of HIV-1 RT/DAPY complex and molecular modeling studies, a series of no...
This paper reports the synthesis and antiviral evaluation of a series of non-nucleoside reverse tran...
A series of novel diarylpyrimidine analogues featuring a hydroxyiminomethyl group between the pyrimi...
A series of novel diarylpyrimidines (DAPYs) with a ketone hydrazone substituent on the methylene lin...
A series of new DAPY-DPEs hybrids, combined the important pharmacophores of DAPYs and DPEs, has been...
By means of structure-based molecular hybridization strategy, a series of novel diarylpyri(mi)dine d...