The 2'-N-formamide derivatives of adenosine, cytidine, and 9-beta-D-arabinofuranosyladenine were synthesized and tested (as triphosphate) for their substrate capacities for the HCV NS5B polymerase.status: publishe
HCV NS5B RNA-dependent RNA polymerase (NS5B) is essential for viral replication and is therefore con...
The carbocyclic analogue of (E)-5-(2-bromovinyl)-2'-deoxyuridine, C-BVDU, is a very potent and selec...
As a part of a broader structure-activity relationship (SAR) study of bicyclic nucleoside analogues ...
The Hepatitis C virus (HCV) is a blood borne virus currently infecting almost 5 million people in th...
Because of the importance of C-branched nucleosides in the discovery of new antiviral molecules, we ...
Nucleoside analogues have long been recognized as prospects for the discovery of direct acting antiv...
The search for new anti-HCV therapeutics continues, as current standard of care based on pegINF and ...
Upon reacting 3',4'-unsaturated cytosine (8 and 9) and adenine nucleosides (13 and 14) with XeF2/BF3...
Among the plethora of synthesized compounds, a number of different analogs have shown interesting ac...
Hepatitis C virus (HCV) infection presents an unmet medical need requiring more effective treatment ...
We report the application of our phosphoramidate ProTide technology to various 4′-substituted ribonu...
Given the impressive success of Gilead's Sofosbuvir, many laboratories, including ours, have explore...
A series of adenosine 5′-phosphonate analogues were designed to mimic naturally occurring adenosine ...
<p>Formyl glycals are the versatile synthetic intermediates and can serves as precursor for the synt...
We report the synthesis of a family of d- and l-furano-d-apionucleosides, their 3'-deoxy, as well as...
HCV NS5B RNA-dependent RNA polymerase (NS5B) is essential for viral replication and is therefore con...
The carbocyclic analogue of (E)-5-(2-bromovinyl)-2'-deoxyuridine, C-BVDU, is a very potent and selec...
As a part of a broader structure-activity relationship (SAR) study of bicyclic nucleoside analogues ...
The Hepatitis C virus (HCV) is a blood borne virus currently infecting almost 5 million people in th...
Because of the importance of C-branched nucleosides in the discovery of new antiviral molecules, we ...
Nucleoside analogues have long been recognized as prospects for the discovery of direct acting antiv...
The search for new anti-HCV therapeutics continues, as current standard of care based on pegINF and ...
Upon reacting 3',4'-unsaturated cytosine (8 and 9) and adenine nucleosides (13 and 14) with XeF2/BF3...
Among the plethora of synthesized compounds, a number of different analogs have shown interesting ac...
Hepatitis C virus (HCV) infection presents an unmet medical need requiring more effective treatment ...
We report the application of our phosphoramidate ProTide technology to various 4′-substituted ribonu...
Given the impressive success of Gilead's Sofosbuvir, many laboratories, including ours, have explore...
A series of adenosine 5′-phosphonate analogues were designed to mimic naturally occurring adenosine ...
<p>Formyl glycals are the versatile synthetic intermediates and can serves as precursor for the synt...
We report the synthesis of a family of d- and l-furano-d-apionucleosides, their 3'-deoxy, as well as...
HCV NS5B RNA-dependent RNA polymerase (NS5B) is essential for viral replication and is therefore con...
The carbocyclic analogue of (E)-5-(2-bromovinyl)-2'-deoxyuridine, C-BVDU, is a very potent and selec...
As a part of a broader structure-activity relationship (SAR) study of bicyclic nucleoside analogues ...
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