Adhesive procedures activate dentin-associated matrix metalloproteinases (MMPs), and so iatrogenically initiate bond degradation. We hypothesized that adding MMP inhibitors to adhesive primers may prevent this endogenous enzymatic degradation, thereby improving bond durability. A nonspecific MMP inhibitor (chlorhexidine) and a MMP-2/9-specific inhibitor (SB-3CT) were admixed to the primers of an etch & rinse and a self-etch adhesive, both considered as gold-standard adhesives within their respective categories. For dentin powder exposed to the adhesives under clinical application conditions, gelatin zymography revealed the release of MMP-2 (not of MMP-9) by the etch & rinse adhesive, while no release of enzymes could be detected for the mil...
Objective Degradation of hybrid layers (HLs) within resin-infiltrated dentine results from multiple...
The use of protein cross-linking agents during bonding procedures has been recently proposed to impr...
The aim of this study was to evaluate the effects of matrix metalloproteinases (MMPs) inhibitors on ...
Endogenous matrix metalloproteinases (MMPs) released by adhesive procedures may degrade collagen in ...
Dentin matrix metalloproteinases (MMPs) are a family of host-derived proteolytic enzymes trapped wit...
Auto-degradation of collagen matrices occurs within hybrid layers created by contemporary dentin bon...
Auto-degradation of collagen matrices occurs within hybrid layers created by contemporary dentin bon...
Objective: Degradation of hybrid layers (HLs) within resin-infiltrated dentine results from multiple...
Degradation of the hybrid layer created in dentin by dentin adhesives is caused by enzyme activities...
Degradation of hybrid layers (HLs) within resin-infiltrated dentine results from multiple degradatio...
Endogenous enzymes may be involved in the biodegradation of adhesive restoration-tooth interfaces. I...
This study aimed to analyze the effect of different matrix metalloproteinase (MMP) inhibitors on the...
none11OBJECTIVE: Degradation of hybrid layers (HLs) within resin-infiltrated dentine results from mu...
The use of protein cross-linking agents during bonding procedures has been recently proposed to impr...
Matrix metalloproteinase (MMP) inhibition has been shown to reduce adhesive bond degradation when ...
Objective Degradation of hybrid layers (HLs) within resin-infiltrated dentine results from multiple...
The use of protein cross-linking agents during bonding procedures has been recently proposed to impr...
The aim of this study was to evaluate the effects of matrix metalloproteinases (MMPs) inhibitors on ...
Endogenous matrix metalloproteinases (MMPs) released by adhesive procedures may degrade collagen in ...
Dentin matrix metalloproteinases (MMPs) are a family of host-derived proteolytic enzymes trapped wit...
Auto-degradation of collagen matrices occurs within hybrid layers created by contemporary dentin bon...
Auto-degradation of collagen matrices occurs within hybrid layers created by contemporary dentin bon...
Objective: Degradation of hybrid layers (HLs) within resin-infiltrated dentine results from multiple...
Degradation of the hybrid layer created in dentin by dentin adhesives is caused by enzyme activities...
Degradation of hybrid layers (HLs) within resin-infiltrated dentine results from multiple degradatio...
Endogenous enzymes may be involved in the biodegradation of adhesive restoration-tooth interfaces. I...
This study aimed to analyze the effect of different matrix metalloproteinase (MMP) inhibitors on the...
none11OBJECTIVE: Degradation of hybrid layers (HLs) within resin-infiltrated dentine results from mu...
The use of protein cross-linking agents during bonding procedures has been recently proposed to impr...
Matrix metalloproteinase (MMP) inhibition has been shown to reduce adhesive bond degradation when ...
Objective Degradation of hybrid layers (HLs) within resin-infiltrated dentine results from multiple...
The use of protein cross-linking agents during bonding procedures has been recently proposed to impr...
The aim of this study was to evaluate the effects of matrix metalloproteinases (MMPs) inhibitors on ...