Synthesis and biological evaluation of carbon-11-and fluorine-18-labeled 2-oxoquinoline derivatives for type 2 cannabinoid receptor positron emission tomography imaging

Introduction: The type 2 cannabinoid (CB2) receptor is part of the endocannabinoid system and has been Suggested as a mediator of several central and peripheral inflammatory processes. Imaging of the CB2 receptor has been unsuccessful so far. We synthesized and evaluated a carbon-11- and a fluorine-18-labeled 2-oxoquinoline derivative as new PET tracers with high specificity and affinity for the CB2 receptor.status: publishe