Comparative evaluation of interpolyelectrolyte complexes of Chitosan with Eudragit® L100 and Eudragit® L100-55 as potential carriers for oral controlled drug delivery
- Moustafine, Rouslan I
- Margulis, Eugenia B
- Sibgatulina, Liliya F
- Kemenova, Vera A
- Van den Mooter, Guy
DOIAbstract
With a view to the application in oral controlled drug delivery systems, the formation of interpolyelectrolyte complexes (IPEC) between chitosan (CS) and Eudragit L100 (L100) or Eudragit L100-55 (L100-55) was investigated at pH 6.0, using elementary analysis. The interaction or binding ratio of a unit molecule of CS with Eudragit L copolymers depends on the molecular weight of CS, and changes from 1:0.85 to 1:1.22 (1.17<phi<0.82) for L100 and from 1:1.69 to 1:1.26 (0.60<phi<0.79) for L100-55, respectively. Based on the results of FT-IR, the structure of the IPECs can change substantially as a function of pH (from 5.8 till 7.4). Swelling behavior of physical mixtures (PM) is definitely different, and potential interactions between the two po...
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