Influence of exonic polymorphisms in the gene for LDL receptor-related protein (LRP) on risk of coronary artery disease

Pocathikorn, Anothai
Granath, Britt
Thiry, Els
Van Leuven, Freddy
Taylor, Roger
Mamotte, Cyril

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Publication date

May 2003

DOI

10.1016/S0021-9150(03)00087-X

Publisher

Elsevier BV

Journal

Atherosclerosis

Abstract

The low density lipoprotein (LDL) receptor-related protein (LRP) is a multifunctional receptor involved in numerous biological processes relevant to vascular biology including lipoprotein metabolism. Several polymorphisms in the LRP gene have been described and in this study we examined their influence on coronary artery disease (CAD). We compared the frequencies of the exon 3 (C766T), exon 6 (C663T), exon 22 (C200T), and four rarer and more recently described polymorphisms in approximately 600 Caucasian subjects aged <50 years with angiographic CAD and approximately 700 similarly aged subjects without symptomatic CAD randomly selected from the community. We found the distribution of exon 22 C200T genotypes to differ significantly between t...