Synthesis and properties of oligonucleotides containing 2,4-dihydroxycyclohexyl nucleosides

Cyclohexyl nucleosides with an adenine and uracil base have been synthesized from 2-azidocyclohexane1,5-diol. The obtained racemic nucleosides were resolved using (R)-O-methylmandelic acid. Short oligonucleotides were synthesized using phorphoramidite chemistry. However, these oligonucleotides do not show self-hybridization, and duplexes are less stable than those of ribopyranosyl-(4' -> 2')-oligonucleotides.status: publishe