Genetic Determinants of Drug Resistance in Mycobacterium tuberculosis and Their Diagnostic Value
- Farhat, Maha R.
- Sultana, Razvan
- Iartchouk, Oleg
- Bozeman, Sam
- Galagan, James
- Sisk, Peter
- Stolte, Christian
- Nebenzahl-Guimaraes, Hanna
- Jacobson, Karen
- Sloutsky, Alexander
- Kaur, Devinder
- Posey, James
- Kreiswirth, Barry N.
- Kurepina, Natalia
- Rigouts, Leen
- Streicher, Elizabeth M.
- Victor, Tommie C.
- Warren, Robin M.
- van Soolingen, Dick
- Murray, Megan
DOI Publisher
American Thoracic Society Journal
American Journal of Respiratory and Critical Care MedicineAbstract
The development of molecular diagnostics that detect both the presence of Mycobacterium tuberculosis in clinical samples and drug resistance-conferring mutations promises to revolutionize patient care and interrupt transmission by ensuring early diagnosis. However, these tools require the identification of genetic determinants of resistance to the full range of antituberculosis drugs
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