Perspectives on Directions and Priorities for Future Preclinical Studies in Regenerative Medicine
- Grigorian Shamagian, Lilian
- Madonna, Rosalinda
- Taylor, Doris
- Climent, Andreu M
- Prosper, Felipe
- Bras-Rosario, Luis
- Bayes-Genis, Antoni
- Ferdinandy, Péter
- Fernández-Avilés, Francisco
- Izpisua Belmonte, Juan Carlos
- Fuster, Valentin
- Bolli, Roberto
DOIAbstract
The myocardium consists of numerous cell types embedded in organized layers of ECM (extracellular matrix) and requires an intricate network of blood and lymphatic vessels and nerves to provide nutrients and electrical coupling to the cells. Although much of the focus has been on cardiomyocytes, these cells make up <40% of cells within a healthy adult heart. Therefore, repairing or regenerating cardiac tissue by merely reconstituting cardiomyocytes is a simplistic and ineffective approach. In fact, when an injury occurs, cardiac tissue organization is disrupted at the level of the cells, the tissue architecture, and the coordinated interaction among the cells. Thus, reconstitution of a functional tissue must reestablish electrical and mechan...
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