Short cycles of ventilation with anesthetic gases prior to or after prolonged cardiac ischemia, called anesthetic pre- or postconditioning, are known to reduce cardiac damage. The underlying mechanisms include the reperfusion injury salvage (RISK) pathway and involve recruitment of molecular signaling via caveolin (Cav) modulation. Postconditioning with helium (HePoc) mimics cardioprotective effects. In the present study using a rat model, we investigated whether (1) HePoc alters protein or mRNA expression of Cav-1 and -3 and (2) activation of RISK pathway and (3) autophagy associated proteins. Heliox ventilation (70% He, 30% O2) was applied after 25 min of ischemia and tissue from ischemic area at risk (AAR), non-ischemic not area at risk...
Heart can usually survive a short period of ischemia, but when this period is too long, damages of t...
Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, p...
In this thesis, three main research questions have been addressed and answered. Firstly we showed th...
Short cycles of ventilation with anesthetic gases prior to or after prolonged cardiac ischemia, call...
Helium, a noble gas, has been used safely in humans. In animal models of regional myocardial ischemi...
The noble gas helium (He) induces cardioprotection in vivo through unknown molecular mechanisms. He ...
The noble gas helium (He) induces cardioprotection in vivo through unknown molecular mechanisms. He ...
Helium protects healthy myocardium against ischemia/reperfusion injury by early and late preconditio...
Background: The noble gas helium induces pre- and postconditioning in animals and humans. Volatile a...
BackgroundThe noble gas helium induces cardio- and neuroprotection by pre- and post-conditioning. We...
The aims of this thesis were to investigate whether helium induces preconditioning in humans, and to...
Ischemia and reperfusion (I/R) injury of the heart can be ameliorated by volatile anesthetics (VAs)....
BACKGROUND: Prosurvival signaling kinases inhibit glycogen synthase kinase-3beta (GSK-3beta) activit...
Caveolins are involved in anaesthetic-induced cardioprotection. Actin filaments are located in close...
ABSTRACT Caveolae, small invaginations in the plasma membrane, contain caveolins (Cav) that scaf-fol...
Heart can usually survive a short period of ischemia, but when this period is too long, damages of t...
Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, p...
In this thesis, three main research questions have been addressed and answered. Firstly we showed th...
Short cycles of ventilation with anesthetic gases prior to or after prolonged cardiac ischemia, call...
Helium, a noble gas, has been used safely in humans. In animal models of regional myocardial ischemi...
The noble gas helium (He) induces cardioprotection in vivo through unknown molecular mechanisms. He ...
The noble gas helium (He) induces cardioprotection in vivo through unknown molecular mechanisms. He ...
Helium protects healthy myocardium against ischemia/reperfusion injury by early and late preconditio...
Background: The noble gas helium induces pre- and postconditioning in animals and humans. Volatile a...
BackgroundThe noble gas helium induces cardio- and neuroprotection by pre- and post-conditioning. We...
The aims of this thesis were to investigate whether helium induces preconditioning in humans, and to...
Ischemia and reperfusion (I/R) injury of the heart can be ameliorated by volatile anesthetics (VAs)....
BACKGROUND: Prosurvival signaling kinases inhibit glycogen synthase kinase-3beta (GSK-3beta) activit...
Caveolins are involved in anaesthetic-induced cardioprotection. Actin filaments are located in close...
ABSTRACT Caveolae, small invaginations in the plasma membrane, contain caveolins (Cav) that scaf-fol...
Heart can usually survive a short period of ischemia, but when this period is too long, damages of t...
Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, p...
In this thesis, three main research questions have been addressed and answered. Firstly we showed th...