Hodgkin's Disease: Results of a single center in Central Anatolia

Turk J Hematol. 2001; 18(2): 117-122Share on twitterShare on facebookShare on emailMore Sharing Services  Hodgkin’s Disease: Results of a Single Center in Central AnatoliaH. Şenol Coşkun1, Bülent Eser2, Mustafa Çetin2, Özlem Er1, Ali Ünal2, Mustafa Altınbaş1, Eray Karahacıoğlu3, Bünyamin Kaplan31Department Of Medical Oncology, Erciyes University Medical Faculty2Department Of Haematology, Erciyes University Medical Faculty3Department Of Radiation Oncology, Erciyes University Medical Faculty, Kayseri, TurkeyHodgkin’s Disease (HD) accounts for about 1% of newly diagnosed malignant diseases. In this study 119 HD cases followed in Erciyes University Hospital were evaluated. 67.2% of the patients was male, 32.8% female. The patients’ age ranged from 15 to 72 years with a median of 41.5 years. Of the patients 10.1% was stage I, 29.4% stage II, 39.5% stage III, and 21.0% stage IV. According to Rye classification frequency of histologicsubtypes was as follows; 21.0% lymphocyte predominant, 25.2% nodular sclerosis, 43.7% mixed cellularity, and 10.1% lymphocyte depletion. Combination chemotherapy consisting cyclophosphamide, vincristine, procarbazine and prednisolone (COPP) was used as first line treatment in 59.7% of patients. Complete remission was achieved in 84.9% of patients and partial remission in 5.0% of patients; response could not be obtained in remaining 10.1% of patients. Disease progression or recurrence was observed in 30.2% of patients. Five year survival rate was found as 70.8% of all patients, 90.1% for stage I-II, 55.3% for stage III-IV patients (p= 0.03).Key words: Hodgkin's Disease, Clinical features, Survival, Adult.