Comparison of two methods for the estimation of subcortical volume and asymmetry using magnetic resonance imaging: a methodological study

The subcortical brain structures are associated with other structures of nervous system; therefore, they have major influence on sensory-motor, limbic and cognitive information processing. Magnetic resonance imaging provides a detailed knowledge of normal and diseased anatomical structures for medical research. The aim of the current study was to compare the volumes of subcortical brain structures and determine the probable volumetric asymmetry in healthy subjects using stereological (point-counting) and semi-automatic segmentation methods