Association of PPARGC1A and CAPNS1 gene polymorphisms and expression with meat quality traits in pigs

Gandolfi, G.
Davoli, R.
Schellander, K.
Phatsara, C.
Tholen, E.
Juengst, H.
Looft, C.
Cinar, M. U.
Ponsuksili, S.
Wimmers, K.
Tesfaye, D.

Publication date

December 2011

DOI

10.1016/j.meatsci.2011.05.015

Abstract

This study aimed to investigate the genes PPARGC1A (peroxisome proliferator-activated receptor gamma-coactivator 1A) and CAPNS1 (calpain small subunit 1) as candidate genes affecting meat quality traits in pigs. Four polymorphisms were identified in PPARCG1A and three in CAPNS1. The PPARGC1A polymorphism c.1288T>A was associated with pH and cooking loss in a F2 Durocx Pietrain experimental cross (DuPi, n =313) and with pH values in Italian Large White (ILW, n=380) and Italian Landrace (ILA, n=158) populations (PC was associated with pH and conductivity in DuPi and with meat color in ILA (P<0.05). PPARGC1A mRNA expression associated with drip loss (P<0.01) and the same tendency was found for CAPNS1 (P= 0.06). The promoter methylation profili...