Dissolution of antibiotics mycelium in ionic liquids: Performance and mechanism

Antibiotics mycelium, byproduct of pharmaceutical industry, contains high percentage of proteins, polysaccharides and lipids, while, the low solubility in traditional solvents limits its utilization. The dissolution process of penicillin mycelium was investigated using ionic liquids (ILs) as solvent. Quantitative correlation of solubility and ILs structure and dissolution mechanism were determined. About 91.45% of penicillin mycelium was dissolved in 1-butyl-3-methylimidazolium acetate (BmimAc) under the condition of 120.0 °C and BmimAc °C, the dissolution of penicillin mycelium increased from 69.74% to 94.50%, with the ratio of DMSO to BmimAc (v β parameter of the ILs. The solubility of mycelium increased with increasing hydrogen bond accepting ability of anions and donating ability of cations