Levosimendan versus dobutamine in heart failure patients treated chronically with carvedilol
- Duygu H.
- Turk U.
- Ozdogan O.
- Akyuz S.
- Kirilmaz B.
- Alioglu E.
- Gunduz R.
- Bozkaya Y.T.
- Turkoglu C.
- Payzin S.
DOIAbstract
PubMed ID: 18786088Introduction: Although beta-blockers are highly effective in the treatment of heart failure (HF), many patients with HF receiving a beta-blocker continue to become decompensated and require hospitalization for worsening HF. Levosimendan and dobutamine are used to manage decompensated HF, but their comparative effects on left ventricular (LV) function in patients prescribed beta-blockers are unknown. Aims: The aim of this study was to compare the effects of dobutamine and levosimendan on LV systolic and diastolic functions in chronic HF patients treated chronically with carvedilol. Forty patients with chronic HF who had NYHA class III to IV symptoms, a LV ejection fraction (LVEF) <40%, and ongoing treatment with carvedilol...
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