Effect of organophosphate intoxication on human serum paraoxonase

WOS: 000176936200004PubMed ID: 12141395Recently, interindividual variations in serum paraoxonase (PON1) activity and the differences in its metabolic activity towards different organophosphates (OPs) caused by the coding region polymorphisms L55M and Q192R have been found to be important risk factors in susceptibility to OP poisoning. In this study, we investigated the effect of PON1 on the outcome of acute OP intoxication and the effect of acute OP intoxication on PON1. Twenty-eight OP-poisoned patients and 66 healthy volunteers were studied. Patients were evaluated for the clinical manifestations of OP intoxication as well as PON1 activity, PON1 mass and PON1 polymorphisms. Butyrylcholine-esterase (BChE) activity was 50% lower (2276+/-738 U/L versus 5037 1553 U/L, P<0.01) while PON1 activity was 30% lower (114.2+/-67.4 nmol/mL/min versus 152.9+/-78.9 nmol/mL/min, P