Antiprotozoal alkaloids from Galanthus trojanus

WOS: 000296534500021Two new alkaloid N-oxides, 1-O-acetyldihydromethylpseudolycorine N-oxide, and 11-hydroxyvittatine N-oxide, ten known alkaloids; arolycoricidine, haemanthamine, O-methylnorbelladine, narcidine, dihydrolycorine, 8-O-demethylmaritidine, stylopine and protopine, nicotinic acid and tyramine were isolated from Galanthus trojanus A. P. Davis & N. Ozhatay (Amaryllidaceae). The chemical structures of the isolates were elucidated by UV, IR, MS, CD, 1D and 2D NMR experiments. The in vitro antiprotozoal and cytotoxic potentials of the compounds were also evaluated. (C) 2011 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.Scientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK); Ege Science and Technology Center (EBILTEM)Ege UniversityThis study was financially supported by the Scientific and Technological Research Council of Turkey (TUBITAK) and by the Ege Science and Technology Center (EBILTEM). B. S. was a recipient of TUBITAK research fellowship. We thank Dr Remo Perozzo for his initial help in enzyme assays. I. L. L. thanks the London School of Pharmacy for PhD scholarship