Two novel saponins from Cephalaria davisiana (Dipsacaceae)

WOS: 000347915800083Two novel hederagenin type triterpene saponins, namely davisianoside A (1) and davisianoside B (2) together with ten known compounds (3-12) were isolated from the aerial parts of Cephalaria davisiana (Dipsacaceae). One new prosapogenin (1a) was also obtained after the alkaline hydrolysis of compound 1. The chemical structures of all compounds were established mainly by 1D-, 2D-NMR and HR-ESI/MS analysis as well as chemical methods. The antibacterial and antifungal effects of compounds 1-2 were evaluated against Gram-positive, Gram-negative bacteria and unicellular yeast C. albicans by MIC method. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.Research Grant Office of Ege University Izmir-TurkeyEge University [2013/Fen/035]; TUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [BIDEB 2211-A]The authors would like to thank to Research Grant Office of Ege University Izmir-Turkey (2013/Fen/035) for financial support, to Prof. Dr. H. Sumbul and Assoc. Prof. Dr. R. S. Gokturk for collection and identification of the plant and to Assoc. Prof. Dr. I. Yasa for antimicrobial activity studies. Thanks are also due to TUBITAK (Marmara Research Centre, Gebze, Kocaeli, Turkey) for NMR and HR-ESI/MS analysis and ARGE-FAR (Ege University, Bornova, Izmir, Turkey) for GC-MS analysis. Kayce is grateful to TUBITAK BIDEB 2211-A for the research fellowship programme