Effects of Pinus brutia bark extract and Pycnogenol (R) in a rat model of carrageenan induced inflammation

WOS: 000272131500005PubMed ID: 19577447The present study was conducted to explore the anti-inflammatory activities of Pinus brutia bark extract and Pycnogenol (R) in a rat model of carrageenan-induced inflammation. Firstly, the compositions of both samples were determined using HPLC Then, carrageenan-induced paw edema was used to assess anti-inflammatory activity in mice Paw volume was measured before and 1, 2, 3, 4, 5 and 6 h after the injection of carrageenan Intraperitoneal administration of both the extract and Pycnogenol (R) inhibited paw swelling dose-dependently at 2, 3, 4, 5 and 6 h after carrageenan injection Both samples exhibited significant anti-inflammatory activities at doses of 75 and 100 mg/kg body wt between 2 and 4 hours after administration (p<0.05), respectively Additionally, P brutia bark extract showed significantly better activity at closes of 75 and 100 mg/kg body wt than indomethacine at the dose of 10 mg/kg body wt. (p