Encapsulated chlorhexidine digluconate usage on the diabetic footwear lining leathers

6th International Conference on Advanced Materials and Systems, ICAMS 2016 -- 20 October 2016 through 22 October 2016 -- 139798It is important for a therapeutic shoe to have a wearable quality and its comfortable use is also prominent in terms of providing an increase in user's quality of life. In long-term treatment of diseases, medical products which are to be manufactured with medical leather materials might be a prominent alternative via local effect application as an adjuvant to the treatment. It is aimed in this study to produce microparticles (MPs) which contain the active agent chlorhexidine digluconate and application of these MPs on lining leather for manufacturing diabetic shoes while providing them a functional quality. Within the scope of the project, MPs loaded with drugs were obtained via spraying chlorhexidine digluconate (CHD) active agent and through spraying with ethyl cellulose polymer and ustulation. In vitro characterisation studies were performed on the acquired MPs. Additionally, active agent quantitation and in vitro drug delivery studies were also performed. Following the studies, the determined optimum MP formulations were applied on the leather, then existence and efficiency of MPs within the leather was shown in the subsequent studies. © 2016 Certex, INCDTP-ICPI