Levels of adiponectin, TNF-alpha, and vascular cell adhesion molecule in the obese women with metabolic syndrome

WOS: 000254256400002Adipocytokines involved in inflammation and the acute phase responders have been found to be increased in the metabolic syndrome (MS). The aim of the study was to compare the 'normal' weight women's fibrinogen, hsCRP, adiponectin, TNF-alpha, vascular cell adhesion molecule (VCAM) with obese patients with MS, and to evaluate the association between fibrinogen, hsCRP, adiponectin, TNF-alpha, VCAM and insulin resistance. The study included 52 obese women who met the criteria for MS defined as in 2001, the National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III) ATP III and 24 normal women. Serum concentrations of glucose (FBG), triglyceride, total and HDL-Cholesterol were determined by enzymatic procedures, serum insulin was measured by chemiluminescence, plasma levels of adiponectin, TNF-alpha and VCAM by Elisa, hsCRP by immunoturbimetric assay and fibrinogen by coagulation method. Measurements of insulin resistance were obtained using the homeostasis model assessment. Mean plasma levels of adiponectin, TNF-alpha, VCAM, fibrinogen and hsCRP were found 6.11 +/- 2.39 mg/ml, 3.10 +/- 3.30 pg/ml, 14.21 +/- 4.00 ng/ml, 375.49 +/- 49.67 mg/dl, 0.33 +/- 0.10 mg/dl in the obese with MS; 6.20 +/- 2.48 mg/ml, 3.01 +/- 1.68 pg/ml, 12.63 +/- 2.54 ng/ml, 304.06 +/- 49.52 mg/dl, 0.30 +/- 0.19 mg/dl in the normal women, respectively. Mean fasting insulin level and HOMA-IR were measured 13.80 +/- 6.32 mU/ml and 3.69 +/- 1.90 mU/ml, respectively in obese with MS. In normal women, fasting insulin level and HOMA-IR were measured 8.30 +/- 3.08 mU/ml and 1.49 +/- 0.37, respectively. Mean levels of adiponectin were positively correlated with mean TNF-alpha levels in the obese with MS (r=0.472, P=0.001). VCAM was negatively correlated with TNF-alpha levels (r=-0.301, p=0.038) in the obese with MS. This study demonstrated that TNF-alpha showed a positive association with adiponectin and a negative association with VCAM in the obese women with MS