Effect of vehicles on in vitro release of metronidazole through different membranes

The invitro release tests is a measure of inprocess control and also as a finished product specification for creams, ointments and gels. The objective of this study was to evaluate the in vitro release and ex-vivo percutaneous absorption of Metronidazole (MTD) from different water soluble and oleaginous vehicles. All of the experiments were conducted using three different barriers (synthetic membrane, excised rat and rabbit skins). Within the barriers tested rat skin was found to be the best alternative to the others. Moreover water soluble vehicles could be suggested as good candidates for the topical delivery of MTD, giving higher drug release