Effects of levosimendan on left atrial functions in patients with ischemic heart failure
- Duygu H.
- Nalbantgil S.
- Ozerkan F.
- Zoghi M.
- Akilli A.
- Erturk U.
- Akin M.
- Nazli C.
- Ergene O.
DOIAbstract
PubMed ID: 19072879Background: With further progression of left ventricular (LV) dysfunction, the left atrial (LA) contribution to LV filling gradually decreases, and LA dysfunction deteriorates the decreased LV filling in patients with heart failure (HF). Hypothesis: This study sought to investigate the effects of levosimendan on LA function in patients with HF. Methods: A total of 60 patients having acute decompensated HF with ischemic cardiomyopathy and LV ejection fraction (LVEF) <40% were included in the study. Patients were randomized to levosimendan (n = 30) or to dobutamine (n = 30). Before and 24 h after treatment, LVEF, mitral inflow peak E and A wave velocity, E/A ratio, mitral lateral annulus peak Em wave velocity, E/Em ratio, L...
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