Vancomycin versus teicoplanin in the therapy of experimental methicillin-resistant Staphylococcus aureus (MRSA) meningitis

Sipahi, OR
Arda, B
Yurtseven, T
Sipahi, H
Ozgiray, E
Suntur, BM
Ulusoy, S

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Publication date

January 2005

DOI

10.1016/j.ijantimicag.2005.08.011

Publisher

Elsevier BV

ISSN

0924-8579

Journal

International Journal of Antimicrobial Agents

Citation count (estimate)

Abstract

15th European Congress of Clinical Microbiology and Infectious Diseases -- APR 02-05, 2005 -- Copenhagen, DENMARKWOS: 000233421000010PubMed ID: 16221540The aim of this study was to compare the antibacterial activity of teicoplanin and vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) meningitis using a rabbit meningitis model. The MRSA strain ATCC 43300 was used to infect the rabbits. The vancomycin group received 20 mg/kg vancomycin every 12 h (q12h), the teicoplanin group received 6 mg/kg teicoplanin q12h and the control group did not receive any treatment. Drug levels were measured using a bioassay technique. Bacterial counts in the treatment groups were significantly lower (P 0.05). These data suggest th...