Risk factors predicting the survival of pediatric patients with relapsed/refractory non-Hodgkin lymphoma who underwent hematopoietic stem cell transplantation: a retrospective study from the Turkish pediatric bone marrow transplantation registry
- Hazar, Volkan
- Kesik, Vural
- Karasuc, Gulsun Tezcan
- Ozturk, Gulyuz
- Kupesiz, Alphan
- Kilic, Suar Caki
- Atas, Erman
- Uygun, Vedat
- Eker, Nursah
- Erbey, Fatih
- Bengoa, Sebnem Yilmaz
- Emir, Suna
- Anak, Sema
- Oniz, Haldun
- Daloglu, Hayriye
- Aksoylar, Serap
- Kocak, Ulker
- Karakukcu, Musa
- Elli, Murat
- Kurucu, Nilgun
- Yesilipek, Akif c
DOIAbstract
WOS: 000412118800010PubMed ID: 28571522We examined outcomes of 62 pediatric patients with relapsed or refractory non-Hodgkin lymphoma (rr-NHL) who underwent hematopoietic stem cell transplantation (HSCT). The overall survival (OS) and event-free survival (EFS) rates were 65% and 48%, respectively. Survival rates for patients with chemosensitive disease at the time of HSCT were significantly higher than those of patients with chemosensitive disease (69% vs. 37%, p = .019 for OS; 54% vs. 12%, p <. 001 for EFS; respectively). A chemoresistant disease at transplantation was the only factor that predicted a limited OS (hazard ratio = 10.00) and EFS (hazard ratio = 16.39) rates. Intensive chemotherapy followed by HSCT could be an effective strate...
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