A New beta-Lapachone Derivative from Distictella elongata (Vahl) Urb

WOS: 000264017600026The present study describes the structure elucidation of the new beta-lapachone type naphthoquinone isolated from the roots of Distictella elongata. Its structure, according to the molecular formula C16H16O6, was identified as 4,7-dihydroxy-10-methoxy-2,2-dimethyl-3,4-dihydro-2H-benzo[h]chromene-5,6-dione. The structure was assigned by spectrometric methods [HRESIMS, 1D NMR (H-1 and C-13), and 2D NMR (g-DQF-COSY, g-HMQC and g-HMBC]. Root chloroform extract of D. elongata showed significant inhibition of the growth of SK-MEL (melanoma) and SK-OV-3 (ovary adenocarcinoma) cells with IC50 values of 40 mu g mL(-1) and 56 mu g mL(-1), respectively. However, the naphthoquinone was not responsible for the cytotoxic activity exhibited by the extract.United States Department of AgricultureUnited States Department of Agriculture (USDA); FAPESP BIOTAFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [99/10610-1]This work was supported in part by the United States Department of Agriculture, ARS Specific Cooperative Research Agreement and by the FAPESP BIOTA project No. 99/10610-1